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RISING STARS: Targeting G protein-coupled receptors to regulate energy homeostasis

Aqfan Jamaluddin

Aqfan Jamaluddin Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Caroline M Gorvin

Caroline M Gorvin Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory peptide, GIP) are gut-derived hormones known as incretins, as they promote the secretion of insulin. GLP-1 is processed from the pro