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multiple transcription factors as well as adaptor proteins ( Essandoh et al. 2016 ). In the current study, bioinformatics analysis has revealed that miR-146a could target toll-like receptor 4 (TLR4), which is also verified by a recent study ( He et al
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backfat thickness tended to be greater in Korean cattle ( Lee et al. 2010 ). However, to our knowledge, the role of ACOX1 in intramuscular adipogenesis of beef cattle has not been reported, and its transcriptional and post-transcriptional regulatory
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Departments of Biochemistry, Medicine and Oncology, McGill University, Montreal, Quebec, Montreal, Canada
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dynamics. These processes are finely tuned by metabolic pathways that sense cellular energy needs and impinge on the activity of key transcription factors to control mitochondrial nuclear-encoded gene expression. Nuclear receptors and their cognate hormone
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
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The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
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important factor for abnormal lipid accumulation in hepatocytes. Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in lipid synthesis and function ( Shimano & Sato 2017 ). SREBPs
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processing of FGF23 protein ( Tagliabracci et al. 2014 ). Therefore, FGF23 concentration and activities can be regulated not only by FGF23 transcription and translation but also by the posttranslational modification of FGF23 protein. Figure 2
Sorbonne Université, CNRS -Institut de Biologie Paris Seine (BIOSIPE), Paris, France
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, steroid hormones interact with nuclear receptors and the complex formed regulates the transcriptional activity of target genes, the promoters of which contain specific sequences (hormone-responsive elements). However, steroids also act at cell membrane
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LF Spicer LJ 2020 Regulation of the transcription factor E2F1 mRNA in ovarian granulosa cells of cattle . Journal of Animal Science 98 1 – 8 . ( https://doi.org/10.1093/jas/skz376 ) Nilsson EE Doraiswamy V Skinner MK 2003
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by O-glycosylation at position T178 through GALNT3, which results in the secretion of the biologically active intact FGF23 ( Tagliabracci et al. 2014 ). The regulation of transcription, production, and post-translational modification of FGF23 has