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Cellular mechanisms of incretin hormone secretion

Marta Santos-Hernández

Marta Santos-Hernández Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK

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Frank Reimann

Frank Reimann Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK

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Fiona M Gribble

Fiona M Gribble Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK

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enteroendocrine signalling pathways. NCI-H716 is a human GLP-1 secreting cell line derived from a poorly differentiated caecal adenocarcinoma ( Reimer et al. 2001 ), which is grown in suspension culture prior to seeding in wells for experimentation. It offers