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Inge Seim Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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Amy A Lubik Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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Melanie L Lehman Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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Nadine Tomlinson Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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Eliza J Whiteside Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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Adrian C Herington Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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Colleen C Nelson Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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Lisa K Chopin Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia

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( Ukkola 2011 ), gastrointestinal disease ( Jeffery et al . 2011 ), cardiovascular disease ( Isgaard & Granata 2011 ), reproductive disorders ( Repaci et al . 2011 ), mental health ( Steiger et al . 2011 ) and cancer ( Chopin et al . 2011 , Deboer 2011

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Frank A Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
The Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Iad Alhallak Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Rosalia C M Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
The Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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NADPH pool. Recent studies have demonstrated that ME1 is pro-oncogenic in a diverse array of epithelial cancers. This review focuses on this new role of ME1 in cancer and potentially at the interface of cancer, diabetes and obesity ( Lega & Lipscombe

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Weiye Zhao Department of Biology, University of York, York, UK

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Susanna F Rose Department of Biology, University of York, York, UK

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Ryan Blake CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Aňze Godicelj Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Smith Building, Boston, Massachusetts, USA

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Amy E Cullen CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Jack Stenning Department of Biology, University of York, York, UK

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Lucy Beevors The Institute of Metabolism and Systems Research (IMSR), University of Birmingham, College of Medical and Dental Sciences, Birmingham, UK

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Marcel Gehrung CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Sanjeev Kumar Chris O’Brien Lifehouse, Sydney, New South Wales, Australia

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Kamal Kishore CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Ashley Sawle CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Matthew Eldridge CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Federico M Giorgi Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

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Katherine S Bridge Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK

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Florian Markowetz CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Andrew N Holding Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK
The Alan Turing Institute, Kings Cross, London, UK

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Introduction Approximately 75% of breast cancers are classified as estrogen receptor-α (ER) positive. In these cancers, the ER is no longer correctly regulated, subverts cell division regulation, and becomes the driving transcription factor in

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Ana Pestana Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal

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João Vinagre Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal

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Manuel Sobrinho-Simões Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal
Medical Faculty, University of Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar S. João, Porto, Portugal
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal

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Paula Soares Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal
Medical Faculty, University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal

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exon 2 ( Cong et al. 1999 , Cukusic et al. 2008 ), where the 181 bp fragment upstream of the transcriptional start site is the core functional promoter essential for transcriptional activation of TERT in cancer cells ( Takakura et al. 1999

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Maria Rossing Centre for Genomic Medicine, Department of Endocrinology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
Centre for Genomic Medicine, Department of Endocrinology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark

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Introduction Thyroid cancer is the most common cancer of the endocrine organs and its incidence has increased over recent decades ( Kondo et al . 2006 ). The majority of thyroid carcinomas derive from follicular thyroid cells, also known as thyroid

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Man Lu Liggins Institute, University of Auckland, Auckland, New Zealand
Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand

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Chantal Buckley Liggins Institute, University of Auckland, Auckland, New Zealand

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Yue Wang Liggins Institute, University of Auckland, Auckland, New Zealand

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Ries J Langley Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand

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Jo K Perry Liggins Institute, University of Auckland, Auckland, New Zealand
Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand

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hormone disorder characterised by excessive GH secretion that most commonly results from a benign pituitary adenoma. Aberrant autocrine/paracrine secretion is also implicated in cancer. Within the tumour microenvironment, GH may be secreted by cancer cells

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Nicola J Smith School of Biosciences, University of Kent, Canterbury, Kent, UK

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Tim R Fenton School of Biosciences, University of Kent, Canterbury, Kent, UK

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Introduction A link between sexual contact and cervical cancer was first reported in 1842, by the Italian physician, Rigoni-Stern ( Rigoni-Stern 1842 ) yet the role of human papillomaviruses (HPVs) as the incriminating infectious agent was not

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Lekha Jain Liggins Institute, University of Auckland, Auckland, New Zealand

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Tayaza Fadason Liggins Institute, University of Auckland, Auckland, New Zealand

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William Schierding Liggins Institute, University of Auckland, Auckland, New Zealand

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Mark H Vickers Liggins Institute, University of Auckland, Auckland, New Zealand

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Justin M O’Sullivan Liggins Institute, University of Auckland, Auckland, New Zealand

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Jo K Perry Liggins Institute, University of Auckland, Auckland, New Zealand

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well-characterised growth disorders and is linked to an altered susceptibility to cancer, diabetes and cardiovascular disorders ( Hannon et al. 2017 , Guevara-Aguirre et al. 2018 , Gadelha et al. 2019 ). In particular, altered GH expression has

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Custodia García-Jiménez
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Jose Manuel García-Martínez
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Ana Chocarro-Calvo
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Antonio De la Vieja Departamento de Fisiología y Bioquímica, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcon, Madrid, Spain

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Introduction Extensive epidemiological studies have revealed that the diabetic population is at higher risk of suffering cancers of the liver, pancreas, endometrium, colon and others ( Shikata et al . 2013 ). Increased cancer risk in the diabetic

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James G Yarger
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Robert E Babine ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Michael Bittner ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Erin Shanle ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Wei Xu ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Pamela Hershberger ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Steven H Nye
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target for drug developers treating human diseases such as cardiovascular, cancer, and autoimmune disorders ( Deroo & Korach 2006 ). Drugs in the market that modulate the activity of nuclear receptors represent over $30 billion in pharmaceutical sales

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