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Hiroshi Ishikawa Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Tatsuya Kobayashi Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan
Fujita Medical Innovation Center Tokyo, Reproduction Center, Tokyo, Japan

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Meika Kaneko Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Yoshiko Saito Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Makio Shozu Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan

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Kaori Koga Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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al. 2023 ). Moreover, MED12-UFs have increased ECM organization, cell adhesion, integrin-mediated signaling pathway, Wnt/β-catenin signaling pathway, and response to estrogen, whereas wt-UFs have increased angiogenic activities and smooth muscle cell

Article Type:
Review Article
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Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0039
Volume/Issue:
Volume 71: Issue 4
Free access
Dorka Nagy Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK
National Heart and Lung Institute, Imperial College London, London, UK

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Hannah Maude Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

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Graeme M Birdsey National Heart and Lung Institute, Imperial College London, London, UK

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Anna M Randi National Heart and Lung Institute, Imperial College London, London, UK

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Inês Cebola Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

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and nutrients are exported into the LSECs and liver parenchyma, while metabolism products and other cell exports enter the blood ( Fig. 1 ). This structure creates a gradient of oxygen, nutrients, and signalling molecules including Wnt morphogens, a

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0026
Volume/Issue:
Volume 71: Issue 2
Open access
Sarah Theresa Boyle Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia

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) and Wnts, and tumor hypoxia exacerbates this pro-angiogenic function ( Mazzieri et al. 2011 , Van Overmeire et al. 2014, De Palma et al. 2017 ). CAFs are also a major source of VEGF, and in mammary tumors formed from ER + cells, they recruit

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-22-0174
Volume/Issue:
Volume 70: Issue 3
Free access