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James G Yarger
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Robert E Babine ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Michael Bittner ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Erin Shanle ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Wei Xu ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Pamela Hershberger ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Steven H Nye
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.05. For the DNA microarray studies, significant ( P <0.001) up- or downregulated genes were identified by comparing the E 2 analog-treated and vehicle-treated samples from each tumor cell line. Genes were included in the relevant signaling pathways

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0083
Volume/Issue:
Volume 50: Issue 1
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Yuka Toyoshima Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Reiko Tokita Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Yoichiro Ohne Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Fumihiko Hakuno Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Tadashi Noguchi Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Shiro Minami Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Hisanori Kato Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Shin-Ichiro Takahashi Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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glycogen, protein, and lipids. Thus, the deterioration of nutritional state could result in the inhibition of insulin-like signaling. On the other hand, some reports have shown that malnutrition enhances insulin sensitivity in various human and animal

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0102
Volume/Issue:
Volume 45: Issue 5
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Colin R Jefcoate Department of Cell and Regenerative Biology and the Endocrinology and Reproductive Physiology Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

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Jinwoo Lee Department of Cell and Regenerative Biology and the Endocrinology and Reproductive Physiology Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

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signaling. Discovering cholesterol networks A new direction in steroid synthesis emerged from the finding that ACTH stimulation of adrenal cholesterol metabolism was rapidly stopped by protein synthesis inhibitors, such as cycloheximide (CHX) ( Davis

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-17-0281
Volume/Issue:
Volume 60: Issue 4
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Pulak R Manna Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Syam P Chandrala Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Youngah Jo Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Douglas M Stocco Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Introduction Regulation of various Leydig cell functions, including steroidogenesis, are predominantly mediated by luteinizing hormone/chorionic gonadotropin (LH/CG) through the involvement of multiple signaling pathways ( Dufau 1988

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02065
Volume/Issue:
Volume 37: Issue 1
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Kent Wehmeier Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, Florida, USA

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Luisa M Onstead-Haas Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, Florida, USA

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Norman C W Wong Department of Medicine, Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada

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Arshag D Mooradian Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, Florida, USA

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Michael J Haas Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, Florida, USA

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ligand binding, VDR and its partner retinoid x receptor (RXR) mediate the transcriptional effects of the hormone on target genes ( Kimmel-Jehan et al. 1997 ). However, recent studies have shown that vitamin D exhibits nongenomic signaling activity

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0009
Volume/Issue:
Volume 57: Issue 2
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Guoqing Lei Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Linxi Chen Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Miao Peng Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Bolin Zeng Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Qiaoxi Yang Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Hening Zhai Endoscopy Center, The First Affiliated Hospital of Jinan University

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Geyang Xu Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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motif-binding site for JAK1/2, which subsequently activates Stat1 and Stat3 pathways. IL-27 also signals through p38 mitogen-activated protein kinase (MAPK) pathway ( Lucas et al. 2003 , Guzzo et al. 2010 , Pot et al. 2011 , Wang et al. 2011

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0124
Volume/Issue:
Volume 63: Issue 3
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Jianqiu Gu Department of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada

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Weijuan Shao Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada

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Dinghui Liu Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China

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Jia Nuo Feng Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

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Juan Pang Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Tianru Jin Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada
Banting and Best Diabetes Centre, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

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Introduction Twenty-two years ago, Ross and colleagues have demonstrated that the activation of canonical Wnt signaling pathway (defined as Wnt pathway hereafter) via the Wnt ligand Wnt10b maintains pre-adipocytes in an undifferentiated state

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0026
Volume/Issue:
Volume 69: Issue 2
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Laura Marroquí Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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Alejandro Gonzalez Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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Patricia Ñeco Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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Ernesto Caballero-Garrido Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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Elaine Vieira Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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Cristina Ripoll Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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Angel Nadal Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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Ivan Quesada Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Bioingeniería, Elche, Spain

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requirements of the organism ( Sachdeva & Stoffers 2009 ). These insulin needs depend on multiple factors, including nutritional status and metabolic, hormonal, and neural signals. This functional plasticity also occurs during physiological or pathological

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0025
Volume/Issue:
Volume 49: Issue 1
Free access
Kelly L Short Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Vicoria, Australia.

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A Daniel Bird Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Vicoria, Australia.
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia

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Bennet K L Seow Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Vicoria, Australia.

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Judy Ng Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Vicoria, Australia.

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Annie R A McDougall The Richie Centre, Hudson Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia

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Megan J Wallace The Richie Centre, Hudson Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia

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Stuart B Hooper The Richie Centre, Hudson Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia

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Timothy J Cole Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Vicoria, Australia.

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knockouts of the GR gene ( Bird et al . 2015 ) have established that GR signaling in the mesenchymal compartment of the lung is particularly crucial for normal lung maturation ( Bird et al . 2014 ). Both global and mesenchymal conditional GR knockout

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0235
Volume/Issue:
Volume 64: Issue 3
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Eva D'Amico Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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Stéphanie Gayral Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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Claude Massart Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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Jacqueline Van Sande Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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Jeremy F Reiter Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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Jacques E Dumont Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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Bernard Robaye Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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Stéphane Schurmans Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), IRIBHM, Department of Biochemistry and Biophysics, Laboratoire de Génétique Fonctionnelle, Welbio, Secteur de Biochimie Métabolique, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium

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extracted from eight different tissues. In Kif3a flox/ + Pax8 Cre/ + mice, an additional 200 bp Δ signal was specifically detected after amplification of DNA extracted from the thyroid and the kidney ( Fig. 1B ). The presence of the Δ signal in these two

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0219
Volume/Issue:
Volume 50: Issue 3
Free access