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Yangli Xie Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

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Siru Zhou Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

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Hangang Chen Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

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Xiaolan Du Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

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Lin Chen Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

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osteocytes . Pediatric Nephrology 28 563 – 568 . ( doi:10.1007/s00467-012-2309-3 ). Bouillon R Carmeliet G Verlinden L van Etten E Verstuyf A Luderer HF Lieben L Mathieu C Demay M 2008 Vitamin D and human health: lessons from

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0012
Volume/Issue:
Volume 53: Issue 1
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Aspasia-Athina Volakaki
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Daniel Lafkas
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Eva Kassi
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Andrew V Schally Department of Biological Chemistry, Research Service (151), Division of Hematology/Oncology, University of Athens Medical School, 75 M. Asias Street, 11527 Athens, Greece
Department of Biological Chemistry, Research Service (151), Division of Hematology/Oncology, University of Athens Medical School, 75 M. Asias Street, 11527 Athens, Greece

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Athanasios G Papavassiliou
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Hippokratis Kiaris
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well as by cancers in which it operates as a stimulator of cell proliferation. Consequently, inhibition of action of GHRH by specific antagonistic peptide analogs may emerge as a novel anticancer strategy ( Schally et al . 2001 , Kiaris et al . 2003

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0106
Volume/Issue:
Volume 41: Issue 5
Free access
Xiang Zhang Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Complex Suite 130, Cincinnati, Ohio 45267, USA

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Shuk-Mei Ho Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Complex Suite 130, Cincinnati, Ohio 45267, USA

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biosynthesis and action ( Martinez-Arguelles & Papadopoulos 2010 ). In this review, we have presented additional insights into this topic. Steroid hormones, thyroid hormone (triiodothyronine and thyroxine), retinoic acid (vitamin A), and calcitriol belong to a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0053
Volume/Issue:
Volume 46: Issue 1
Free access
Bogusz Trojanowicz AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany
AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Anja Winkler AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Kathrin Hammje AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Zhouxun Chen AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany
AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Carsten Sekulla AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Dagobert Glanz AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Cornelia Schmutzler AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Birgit Mentrup AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Sabine Hombach-Klonisch AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Thomas Klonisch AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Rainer Finke AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Josef Köhrle AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Henning Dralle AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Cuong Hoang-Vu AG Experimentelle & Chirurgische Onkologie, Universitätsklinik und Poliklinik für Kinderchirurgie, Institut für Physiologische Chemie, Institut für Experimentelle Endokrinologie, Orthopedic Center for Musculoskeletal Research, Department of Human Anatomy & Cell Science, Universitätsklinik und Poliklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Martin-Luther Universität, Magdeburger Strasse 18, 06097 Halle/S., Germany

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Introduction The vitamin A (retinol)-derived retinoic acids (RA) are important regulators of a diverse spectrum of physiological processes, including cell proliferation, differentiation, morphogenesis, angiogenesis, and apoptosis ( Maden 2000

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0118
Volume/Issue:
Volume 42: Issue 3
Free access
K D Senali Abayratna Wansa Institute for Molecular Bioscience, University of Queensland St Lucia, 4072 Queensland, Australia

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George E O Muscat Institute for Molecular Bioscience, University of Queensland St Lucia, 4072 Queensland, Australia

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nuclear hormone receptor Nurr1. Journal of Biological Chemistry 278 24791 –24799. Perlmann T & Jansson L 1995 A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01739
Volume/Issue:
Volume 34: Issue 3
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Pabitra B Pal Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

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Himangshu Sonowal Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

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Kirtikar Shukla Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

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Satish K Srivastava Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

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Kota V Ramana Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

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Arnold JM Ross C Arnold A Sleight P Probstfield J , 2005 Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial . JAMA 293 1338 – 1347 . ( https://doi.org/10.1001/jama.293.11.1338 ) 10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0080
Volume/Issue:
Volume 63: Issue 1
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D Bouton INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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H Escriva INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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R L de Mendonça INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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C Glineur INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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B Bertin INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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C Noël INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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M Robinson-Rechavi INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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A de Groot INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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J Cornette INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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V Laudet INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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R J Pierce INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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receptors RXR α, β and γ, which bind 9- cis RA. The latter play a central role in a variety of nuclear signaling pathways ( Mangelsdorf & Evans 1995 ) and, in vertebrates, modulate the activities of other nuclear receptors (including RAR, the vitamin D

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01766
Volume/Issue:
Volume 34: Issue 2
Free access
Shulin Zhang Department of Molecular and Medical Genetics, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8

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Melinda Chan Department of Molecular and Medical Genetics, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8

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Jane E Aubin Department of Molecular and Medical Genetics, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8

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dexamethasone. Journal of Cell Biology 106 2139 –2151. Grigoriadis AE , Aubin JE & Heersche JN 1989 Effects of dexamethasone and vitamin D3 on cartilage differentiation in a clonal chondrogenic cell population. Endocrinology

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01900
Volume/Issue:
Volume 36: Issue 3
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Ronald M Evans Investigator, Howard Hughes Medical Institute and Professor, Salk Institute for Biological Studies, La Jolla, CA, USA

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Nuclear receptors (NRs) comprise a large family of signal dependent transcription factors that respond to a diverse range of fat soluble ligands including steroids, vitamins A and D, long chain fatty acids, bile acids, thyroid hormone and xenobiotic

Article Type:
Editorial
DOI:
https://doi.org/10.1530/JME-13-0257
Volume/Issue:
Volume 51: Issue 3
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Nikolaos Volakakis
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Michal Malewicz
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Banafsheh Kadkhodai
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Thomas Perlmann
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Gerard Benoit
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vitamin D3, thyroid hormone, and retinoids ( Mangelsdorf et al. 1995 ). NRs encompass several distinct functional domains. A highly conserved DNA-binding domain is utilized for specific DNA binding to hormone-response elements localized in the promoters

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02106
Volume/Issue:
Volume 37: Issue 2
Free access