Introduction Hypoxia-inducible factor-1 (HIF1), a critical transcription factor, regulates cellular hypoxic response in oxygen-lacking cells and is rapidly degraded through the ubiquitin-proteasome pathway under normoxic conditions ( Semenza
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Xueting Wang, Zhiran Zou, Zhihui Yang, Shan Jiang, Yapeng Lu, Dan Wang, Zhangji Dong, Sha Xu, and Li Zhu
Eugenia Mata-Greenwood, P Naomi Jackson, William J Pearce, and Lubo Zhang
endothelial cells (HUVECs) that were resistant to in vitro stimulation by DEX had an increased expression of the E3 ubiquitin ligase gene BCL2-athanogene 1 ( BAG1 ) and subsequent GR protein ubiquitination and proteasomal degradation. It was found that the
Gilberto Paz-Filho, Claudio Alberto Mastronardi, Brian J Parker, Ainy Khan, Antonio Inserra, Klaus I Matthaei, Monika Ehrhart-Bornstein, Stefan Bornstein, Ma-Li Wong, and Julio Licinio
Analysis Pathway Mean FCs Unadjusted P value Adjusted P value KEGG Cell cycle −4.04 3.7×10 −5 0.0063 Ubiquitin-mediated proteolysis −3.02 1.4×10 −3 0.0873 Chronic myeloid leukemia −3.01 1.5×10 −3 0.0873 Biosynthesis of unsaturated fatty acids −2
Yuumi Ishizuka, Kazuhiro Nakayama, Ayumi Ogawa, Saho Makishima, Supichaya Boonvisut, Atsushi Hirao, Yusaku Iwasaki, Toshihiko Yada, Yoshiko Yanagisawa, Hiroshi Miyashita, Masafumi Takahashi, Sadahiko Iwamoto, and Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan
shared among the three tribbles proteins and it is the binding site for E3 ubiquitin ligase constitutive photomorphogenic protein 1 (COP1) that participates in the proteasome-mediated degradation of some targets of tribbles ( Qi et al . 2006 , Yokoyama
Kenneth Siddle
). Grb10 additionally promotes receptor degradation by recruitment of the ubiquitin ligase NEDD4 ( Vecchione et al . 2003 , Ramos et al . 2006 ), while both Grb10 and Grb14 recruit additional protein-binding partners with potential signalling roles
Irene I Lee, Nane C Kuznik, Jaice T Rottenberg, Myles Brown, and Andrew C B Cato
Schematic diagram of the structure of the human BAG proteins. Shown are the BAG domain, the ubiquitin-like domain (UBL), the nuclear localization sequence (NLS), the WW domain, the IPV (Ile-Pro-Val) motifs and the PXXP sequence. The domains of the proteins
Eui Hyun Kim, Geon A Kim, Anukul Taweechaipaisankul, Seok Hee Lee, Muhammad Qasim, Curie Ahn, and Byeong Chun Lee
system using ubiquitin because its decrease is related to decreased cell proliferation ( Sanchez-Diaz et al. 2017 ). It is known that OS and apoptosis have mutual interactions ( Kannan & Jain 2000 ) and also the antioxidative mechanism of melatonin is
Liping Luo, Wanxiang Jiang, Hui Liu, Jicheng Bu, Ping Tang, Chongyangzi Du, Zhipeng Xu, Hairong Luo, Bilian Liu, Bo Xiao, Zhiguang Zhou, and Feng Liu
, suggesting that ER stress-induced hepatic Grb10 gene reactivation might play a role in the production or stability of those metabolic enzymes. GRB10 has been reported to interact with E3 ubiquitin ligase NEDD4 ( Morrione et al . 1999 , Huang & Szebenyi
Niamh Cosgrave, Arnold D K Hill, and Leonie S Young
both transcriptional and post-translational; the latter mediated by the ubiquitin-proteosome pathway ( Zhao et al. 2000 ). Cyclin B1/p34 cdc phosphorylates survivin at Thr 34 ; a modification required for survivin’s anti-apoptotic activity ( O
Victor Quereda and Marcos Malumbres
concentration of their activators (cyclins) or inhibitors (CDK inhibitors or CKIs), which are regulated by specific transcriptional induction by mitogenic and anti-mitogenic pathways and proteolysis by the ubiquitin-proteosome system. A variety of cyclin and CDK
