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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Department of Zoology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Reproductive Endocrinology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Medicine, Zhejiang University. Female ICR mice aged 6–8 weeks in estrus were bred with male ICR mice aged 8–10 weeks, and the day when vaginal plugging was observed was considered as day 1 of pregnancy. At day 3, pregnant mice were anesthetized at 09:00 h
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Introduction Hemolysis (H), elevated liver enzymes (EL), and low platelet count (LP) were termed as the HELLP syndrome ( Weinstein 1982 ). The HELLP syndrome is diagnosed in about 0.5–1% of pregnancy patients, and the majority of the patients
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Singapore Institute for Clinical Sciences, Canadian Neuroepigenetics Network, Agency for Science, Technology and Research (A*STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Singapore
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cell survival ( Meyer 1983 , Lupien et al . 2009 ). Nevertheless, treatments that elevate glucocorticoid levels during late pregnancy compromise brain development and correlate with poorer cognitive performance in humans ( Damsted et al . 2011 ). A
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Introduction In adult life of female mammals, the mammary gland undergoes cycles of developmental changes initiated by pregnancy. These changes can be divided into four consecutive, but partially overlapping stages: mammogenesis, lactogenesis
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Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
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Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
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Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
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Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Academy for Preventive Medicine, Wuhan, Hubei, China
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Introduction Decidualization is an indispensable process for successful pregnancy in both rodents and humans, which indicates the transformation of endometrial stromal fibroblasts into specialized secretory decidual cells ( Gellersen & Brosens
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Introduction Embryo implantation is the first step to establish a successful pregnancy, which requires a normal endometrial receptivity and a functional embryo ( Garrido-Gomez et al. 2012 ). With the attachment between trophoblasts in embryo
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Division of Nephrology and Hypertension, Department of Internal Medicine
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et al. 2016 ). Our group reported that high circulating s(P)RR concentration in maternal blood at early pregnancy predicted subsequent blood pressure elevation ( Watanabe et al. 2012 ), and high plasma s(P)RR at delivery was associated with
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responsiveness induced by the elevated levels of hCG that occur during pregnancy is not desirable. The experiments presented here were designed to test this hypothesis by examining the hormone-induced loss of cell surface receptors and responsiveness in
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testosterone production in the male. A third glycoprotein hormone, the chorionic gonadotropin (CG), is essential for establishing pregnancy as it is the first biochemical signal from the embryo and ‘rescues’ the corpus luteum ( Bousfield & Ward 2006 ). Moreover
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Expression of a variant acetyl-CoA carboxylase-alpha (ACC-alpha) mRNA encoding an isozyme either comprising (+24nt) or lacking (Delta24nt) an eight amino acid domain proximal to the Ser-1200 phosphorylation motif has been investigated in ovine and rat mammary tissue throughout pregnancy and lactation. The ratio of the Delta24nt mRNA: +24nt mRNA in ovine tissues varied from 0.1-0.25 (spleen, lung, muscle, heart, adipose tissue, brain) to 0.6-0.8 (pancreas, liver, kidney) to approximately 5.0 (lactating mammary gland). The sixfold increase in total ACC-alpha mRNA expression in mammary gland during lactation was due entirely to a tenfold increase in the level of the Delta24nt species as the level of expression of the +24nt species remained unaltered between pregnancy and lactation. This mode of expression of the +24nt and Delta24nt mRNAs was similar in rat mammary gland. Between day 20 of pregnancy and day 4 of lactation the ratio of the Delta24nt : +24nt mRNA increased from 2:1 to 10-20:1. Forced involution reduced the ratio of the two mRNAs to levels observed throughout pregnancy. Treatment of lactating rats with bromocryptine reduced the ratio of the Delta24nt : +24nt mRNA to relative levels observed after forced involution, suggesting that the exonic splicing responsible for the generation of the two mRNA isoforms is prolactin responsive.
