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Belinda J Petri Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

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Carolyn M Klinge Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA
University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), Louisvillle, Kentucky, USA

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Introduction Breast cancer (BC) is the most commonly diagnosed cancer worldwide, although countries with the highest human development index, related to life expectancy, education, and wealth, have the highest incidence of BC ( Wilkinson

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0110
Volume/Issue:
Volume 70: Issue 2
Free access
Maria D'Agostino
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Marialuisa Sponziello Department of Health Sciences, Departments of Internal Medicine and Medical Specialties, Surgical Sciences, Department of Medical and Biological Sciences, University of Catanzaro ‘Magna Graecia’, Campus ‘S. Venuta’, Viale Europa, Germaneto, 88100 Catanzaro, Italy

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Cinzia Puppin Department of Health Sciences, Departments of Internal Medicine and Medical Specialties, Surgical Sciences, Department of Medical and Biological Sciences, University of Catanzaro ‘Magna Graecia’, Campus ‘S. Venuta’, Viale Europa, Germaneto, 88100 Catanzaro, Italy

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Marilena Celano
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Valentina Maggisano
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Federica Baldan Department of Health Sciences, Departments of Internal Medicine and Medical Specialties, Surgical Sciences, Department of Medical and Biological Sciences, University of Catanzaro ‘Magna Graecia’, Campus ‘S. Venuta’, Viale Europa, Germaneto, 88100 Catanzaro, Italy

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Marco Biffoni Department of Health Sciences, Departments of Internal Medicine and Medical Specialties, Surgical Sciences, Department of Medical and Biological Sciences, University of Catanzaro ‘Magna Graecia’, Campus ‘S. Venuta’, Viale Europa, Germaneto, 88100 Catanzaro, Italy

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Stefania Bulotta
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Cosimo Durante Department of Health Sciences, Departments of Internal Medicine and Medical Specialties, Surgical Sciences, Department of Medical and Biological Sciences, University of Catanzaro ‘Magna Graecia’, Campus ‘S. Venuta’, Viale Europa, Germaneto, 88100 Catanzaro, Italy

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Sebastiano Filetti Department of Health Sciences, Departments of Internal Medicine and Medical Specialties, Surgical Sciences, Department of Medical and Biological Sciences, University of Catanzaro ‘Magna Graecia’, Campus ‘S. Venuta’, Viale Europa, Germaneto, 88100 Catanzaro, Italy

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Giuseppe Damante Department of Health Sciences, Departments of Internal Medicine and Medical Specialties, Surgical Sciences, Department of Medical and Biological Sciences, University of Catanzaro ‘Magna Graecia’, Campus ‘S. Venuta’, Viale Europa, Germaneto, 88100 Catanzaro, Italy

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Diego Russo
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Introduction Loss of differentiation is a common feature of thyroid cancers, and it has important prognostic implications. Radioactive iodine is the most effective method for managing recurrent and metastatic disease in these patients, but it

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0160
Volume/Issue:
Volume 52: Issue 2
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Stefania Bulotta
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Rosanna Corradino
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Marilena Celano
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Jessica Maiuolo
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Maria D'Agostino
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Manuela Oliverio
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Antonio Procopio
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Sebastiano Filetti Department of Health Sciences, Department of Internal Medicine and Medical Specialties, University ‘Magna Græcia’ of Catanzaro, Viale Europa, Germaneto, Campus ‘S. Venuta’, 88100 Catanzaro, Italy

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Diego Russo
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Introduction The last decades have registered an increased incidence of differentiated thyroid cancer (DTC), including those unable to concentrate iodide and, for this reason, unresponsive to the current radioiodine-based treatment ( Schlumberger

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0241
Volume/Issue:
Volume 51: Issue 1
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Bin Chen Division of Molecular Medicine, Department of Surgical Research

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Yuanzhong Wang Division of Molecular Medicine, Department of Surgical Research

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Susan E Kane Division of Molecular Medicine, Department of Surgical Research

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Shiuan Chen Division of Molecular Medicine, Department of Surgical Research

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Introduction The ERBB2 oncogene encodes a 185 kDa transmembrane tyrosine kinase receptor, belonging to the epidermal growth factor receptor family that is amplified or overexpressed in 30% of breast cancers and is a poor prognostic factor ( Slamon

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0026
Volume/Issue:
Volume 41: Issue 5
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Masaki Shiota Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Akira Yokomizo Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Seiji Naito Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Introduction The androgen/androgen receptor (AR) signaling pathway is known to play a critical role in prostate tumorigenesis and prostate cancer (PCa) progression. Androgen-deprivation therapy (ADT) either reduces the production of androgens by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0018
Volume/Issue:
Volume 47: Issue 1
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Lai Jin Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Qichun Zhang Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Rui Guo Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Lina Wang Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Juejin Wang Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Rong Wan Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Rongjian Zhang Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Youhua Xu Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Shengnan Li Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Introduction Corticotropin-releasing factor (CRF) and Urocortin (Ucn) have been found to be over-expressed in human reproductive tumors such as ovarian cancer ( Suda et al . 1986 ), endometrial adenocarcinoma ( Miceli et al . 2009 ), and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0048
Volume/Issue:
Volume 47: Issue 2
Free access
L C Murphy Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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B Peng Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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A Lewis Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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J R Davie Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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E Leygue Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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A Kemp Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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K Ung Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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M Vendetti Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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R Shiu Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Introduction Oestrogens are considered to be major driving forces in breast tumourigenesis and breast cancer progression ( Colditz 1998 , Clemons & Goss 2001 ). Current evidence suggests that oestrogen action is primarily mediated

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01688
Volume/Issue:
Volume 34: Issue 2
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Natalia Calvo Departamento de Biología, Bioquímica y Farmacia, INBIOSUR, Universidad Nacional del Sur (UNS) – CONICET, Bahía Blanca, Argentina

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Pedro Carriere Departamento de Biología, Bioquímica y Farmacia, INBIOSUR, Universidad Nacional del Sur (UNS) – CONICET, Bahía Blanca, Argentina

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María Julia Martin Departamento de Biología, Bioquímica y Farmacia, INBIOSUR, Universidad Nacional del Sur (UNS) – CONICET, Bahía Blanca, Argentina

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Claudia Gentili Departamento de Biología, Bioquímica y Farmacia, INBIOSUR, Universidad Nacional del Sur (UNS) – CONICET, Bahía Blanca, Argentina

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also use a bipartite multibasic nuclear localization signal to translocate to the nucleus and act through an intracrine pathway ( McCauley & Martin 2012 ). There is evidence that the hormone is implicated in different cancers such as colon carcinoma

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0216
Volume/Issue:
Volume 59: Issue 1
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Lijuan Yin Department of Pathophysiology, The Second Military Medical University, Shanghai, China

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Fang Fang Department of Obstetrics and Gynecology, Changhai Hospital, The Second Military Medical University, Shanghai, China

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Xinglei Song Department of Pathophysiology, The Second Military Medical University, Shanghai, China

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Yan Wang Department of Pathophysiology, The Second Military Medical University, Shanghai, China

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Gaoxiang Huang Department of Pathophysiology, The Second Military Medical University, Shanghai, China

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Jie Su Department of Pathophysiology, The Second Military Medical University, Shanghai, China

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Ning Hui Department of Obstetrics and Gynecology, Changhai Hospital, The Second Military Medical University, Shanghai, China

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Jian Lu Department of Pathophysiology, The Second Military Medical University, Shanghai, China

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cancer therapy of solid malignant tumors because of their beneficial effectiveness in treatment-related edema, inflammation, pain, and electrolyte imbalance ( Rutz 2002 , Rutz & Herr 2004 ). GCs are also given before, during, and after chemotherapy of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0142
Volume/Issue:
Volume 57: Issue 1
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Katherine A Leehy Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Tarah M Regan Anderson Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Andrea R Daniel Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Carol A Lange Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Julie H Ostrander Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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drivers of hormone-associated cancers. ERs and ARs are primary therapeutic targets for breast and prostate cancers, respectively, due to their role in cancer proliferation or survival and tumor progression. These receptors have recently been shown to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0322
Volume/Issue:
Volume 56: Issue 3
Free access