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Centre for Endocrinology, Diabetes and Metabolism (CEDAM), Birmingham Health Partners, Birmingham, UK
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Centre for Endocrinology, Diabetes and Metabolism (CEDAM), Birmingham Health Partners, Birmingham, UK
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, steroid disulfates and 11-oxo-androgens. Vitamin D 25-Hydroxy-vitamin D3-3-sulfate (25-OH-D3-S) is a major metabolite of vitamin D3 found in the systemic circulation ( Axelson 1985 ). As circulating concentrations of 25OH-D3-3-O-sulfate seem not to
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-dihydroxyvitamin D 3 (1α,25(OH) 2 D 3 ) plays a central role in skeletal metabolism by binding to its nuclear steroid receptor, vitamin D receptor (VDR). 1α,25(OH) 2 D 3 can stimulate bone formation and resorption, regulating bone turnover by acting on both
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. 2014 ). The zebrafish retinoic acid receptors (RARs) Retinoic acid (RA) is the active metabolite of vitamin A. The importance of vitamin A in embryonic development has been recognized since ancient times, even though its molecular identity was
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explain the discrepancy between the previous reports showing that vitamin D enhanced ( Yahata et al . 2003 ) or suppressed renal Stc2 gene expression ( Honda et al . 1999 ). In conclusion, we have identified a novel STC2 amino acid sequence in opossum
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heterodimeric complex has been formed with RXR, the complex binds to specific response elements in the promoter region of target genes ( Guibourdenche et al . 2000 ). Heterodimeric partners of RXR include the retinoid A receptor (RARα, β, γ), vitamin D receptor
Université de Nantes, UFR Odontologie, Nantes, France
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Université de Nantes, UFR Odontologie, Nantes, France
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toxicity. Serum Pi concentrations are maintained within a narrow range mainly due to the coordinated action of PTH, FGF23 and vitamin D. While significant progress has been made in understanding the regulation of Pi homeostasis over the last 25 years, the
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Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China
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872 – 883 . ( doi:10.1136/gutjnl-2014-307142 ) Belzer C de Vos WM 2012 Microbes inside – from diversity to function: the case of Akkermansia . ISME Journal 6 1449 – 1458 . ( doi:10.1038/ismej.2012.6 ) Bendich A 1988 Vitamin E
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Introduction Diabetic nephropathy (DN), a serious microvascular complication of diabetes, remains the leading cause of chronic kidney disease and end-stage renal disease ( Fan et al. 2017 , Flyvbjerg 2017 ). Excess extracellular matrix (ECM
Institute of Human Genetics, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Institute for Human Genetics, Ernst-Moritz-Arndt University, Fleischmannstrasse 42/44, 17489 Greifswald, Germany
University Children’s Hospital, Department of Perinatology: Gerhard-Hauptmann-Str. 35, 39108 Magdeburg, Germany
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Institute of Human Genetics, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Institute for Human Genetics, Ernst-Moritz-Arndt University, Fleischmannstrasse 42/44, 17489 Greifswald, Germany
University Children’s Hospital, Department of Perinatology: Gerhard-Hauptmann-Str. 35, 39108 Magdeburg, Germany
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Institute of Human Genetics, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Institute for Human Genetics, Ernst-Moritz-Arndt University, Fleischmannstrasse 42/44, 17489 Greifswald, Germany
University Children’s Hospital, Department of Perinatology: Gerhard-Hauptmann-Str. 35, 39108 Magdeburg, Germany
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Institute of Human Genetics, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Institute for Human Genetics, Ernst-Moritz-Arndt University, Fleischmannstrasse 42/44, 17489 Greifswald, Germany
University Children’s Hospital, Department of Perinatology: Gerhard-Hauptmann-Str. 35, 39108 Magdeburg, Germany
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Institute of Human Genetics, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Institute for Human Genetics, Ernst-Moritz-Arndt University, Fleischmannstrasse 42/44, 17489 Greifswald, Germany
University Children’s Hospital, Department of Perinatology: Gerhard-Hauptmann-Str. 35, 39108 Magdeburg, Germany
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Institute of Human Genetics, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Institute for Human Genetics, Ernst-Moritz-Arndt University, Fleischmannstrasse 42/44, 17489 Greifswald, Germany
University Children’s Hospital, Department of Perinatology: Gerhard-Hauptmann-Str. 35, 39108 Magdeburg, Germany
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Institute of Human Genetics, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Institute for Human Genetics, Ernst-Moritz-Arndt University, Fleischmannstrasse 42/44, 17489 Greifswald, Germany
University Children’s Hospital, Department of Perinatology: Gerhard-Hauptmann-Str. 35, 39108 Magdeburg, Germany
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an intracellular protein involved in the transmission of the vitamin A-derived signal, which regulates genes responsible for lipid metabolism and adipocyte differentiation ( Carr et al. 1998 ). Although the phenotypes of HAART
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parts of the brain. By virtue of their ability to form heterodimers with other NRs such as retinoic acid (RARs), thyroid hormone (TRs), peroxisome proliferator-activated (PPARs), or vitamin D3 receptors, RXRs control a variety of pathophysiological