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Department of Physiology, Aging-associated Vascular Disease Research Center, Departments of Thoracic and Cardiovascular Surgery, Biochemistry and Molecular Biology
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Department of Physiology, Aging-associated Vascular Disease Research Center, Departments of Thoracic and Cardiovascular Surgery, Biochemistry and Molecular Biology
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AB Guleria RS Nizamutdinova IT Baker KM Pan J 2012 High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling . Journal of Cellular Physiology 227 2632 – 2644 . ( doi:10.1002/jcp
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motifs and a 10th LXXML motif mapped to the C-terminus on RIP140 protein. The LXXML motif is required for interaction with retinoic acid receptor (RAR) and retinoic X receptor (RXR) ( Christian et al . 2006 ) ( Fig. 1 ). Coregulator interactions with
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1994 The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO Journal 13 1425 –1433.
Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
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Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
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Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
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Regulation of nuclear receptor action by BAG1 family of proteins. Cochaperone Nuclear receptor Hormone binding DNA binding Transactivation Reference BAG1 GR Repressed n.d. n.d. Kanelakis et al. (1999) BAG1 RAR
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pathway in MCF-7 cells Muller et al . (2003) Histone-modifying enzymes Histone acetyltransferase (HATs, a large family) Activation RAR α and RXR α negatively regulate CLOCK gene expression in vascular cells; androgen deprivation increases EP300
Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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distinct media. Matsumoto and colleagues based their media on mTSCs and showed isolation and maintenance of cynTSCs from primate blastocysts using FGF4, heparin, a pan-RAR inverse agonist (BMS493), and a ROCK inhibitor (Y-27632) ( Matsumoto et al. 2023
Departments of Biochemistry and Molecular Biology and
Physiology, Faculty of Sciences, University of Las Palmas, 35017 Las Palmas, Grand Canaria, Spain
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Departments of Biochemistry and Molecular Biology and
Physiology, Faculty of Sciences, University of Las Palmas, 35017 Las Palmas, Grand Canaria, Spain
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Departments of Biochemistry and Molecular Biology and
Physiology, Faculty of Sciences, University of Las Palmas, 35017 Las Palmas, Grand Canaria, Spain
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Departments of Biochemistry and Molecular Biology and
Physiology, Faculty of Sciences, University of Las Palmas, 35017 Las Palmas, Grand Canaria, Spain
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Departments of Biochemistry and Molecular Biology and
Physiology, Faculty of Sciences, University of Las Palmas, 35017 Las Palmas, Grand Canaria, Spain
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Departments of Biochemistry and Molecular Biology and
Physiology, Faculty of Sciences, University of Las Palmas, 35017 Las Palmas, Grand Canaria, Spain
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factors have been shown to interact with numerous nuclear hormone receptors (AR (androgen receptor), ERα, PR (progesterone receptor), GR (glucocorticoid receptor), CAR (Nr1i3; nuclear hormone receptor subfamily 1, group I, member 3), RAR (retinoic acid
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receptor) RAR-related orphan receptor alpha (ROR-α), Thyroid hormone receptor beta, vitamin D receptor, and peroxisome proliferator-activated receptor gamma (PPAR-γ) were significantly downregulated in CAFs, receptors DAX-1 (dosage-sensitive sex reversal
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. ( doi:10.1101/sqb.2008.73.040 ). Zechel C Shen XQ Chambon P Gronemeyer H 1994 Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements . EMBO Journal 13
Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
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Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
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Forkhead box P3 NFAT Nuclear factor of activated T-cells BATF Basic leucine zipper transcription factor, ATF-like RORG RAR-related orphan receptor C MAF V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) EP300 E1A binding protein p300 GATA3 and
