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St. Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
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Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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elective medical or surgical termination of pregnancy during the first trimester (8–12 weeks) of pregnancy. Term placentas from uncomplicated pregnancies (37–42 weeks) were collected within 30 min of vaginal or elective caesarean delivery (Supplementary
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China
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Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China
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Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China
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Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China
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Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China
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Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China
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Introduction Gestational diabetes mellitus (GDM) is the most common pregnancy complication in the context of the global obesity epidemic ( Wang et al. 2022 ). GDM begets various adverse perinatal outcomes and increases the long-term risks of
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with functions that can be influenced by genetic and epigenetic changes. Interestingly, mutations in metalloproteinase pregnancy-associated plasma protein-A2 (PAPP-A2), one of the proteases believed to increase the local bioavailability of IGFs by
Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre of the Ludwig-Maximilians University, Munich, Germany
Physiology-Weihenstephan, Technical University of Munich, Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Berlin, Germany
Bavarian Research Centre for Biology of Reproduction, Oberschleissheim, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians University, Munich, Germany
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, implantation and pregnancy ( Godkin & Dore 1998 , Tabibzadeh 2002 ). Furthermore, the induction of TGF-β mRNAs and proteins by oestrogen has been shown in epithelial cells of the mouse endometrium ( Nelson et al. 1992 ). This fits very well with the results
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Introduction Decidualisation is a fundamental process of endometrial remodelling that is required for the establishment of pregnancy. It is associated with unique time-dependent transcriptomic and proteomic changes (reviewed in Gellersen
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myometrial stromal cells during pregnancy, although the major source in the myometrium is thought to be macrophages and other leukocytes ( Yelavarthi et al. 1991 , Tabibzadeh et al. 1994 , Young et al. 2002 ). It stimulates the production of
Epidemiology and Biostatistics and
Obstetrics and Gynecology, University of Illinois at Chicago, 835 South Wolcott, Chicago, Illinois 60612, USA
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Epidemiology and Biostatistics and
Obstetrics and Gynecology, University of Illinois at Chicago, 835 South Wolcott, Chicago, Illinois 60612, USA
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Epidemiology and Biostatistics and
Obstetrics and Gynecology, University of Illinois at Chicago, 835 South Wolcott, Chicago, Illinois 60612, USA
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Epidemiology and Biostatistics and
Obstetrics and Gynecology, University of Illinois at Chicago, 835 South Wolcott, Chicago, Illinois 60612, USA
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Epidemiology and Biostatistics and
Obstetrics and Gynecology, University of Illinois at Chicago, 835 South Wolcott, Chicago, Illinois 60612, USA
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Introduction Glycodelin, a 28 kDa glycoprotein, is the most abundant secretory product of the human uterine glandular epithelial cells during the late luteal phase of the menstrual cycle and early pregnancy ( Bell et al. 1985 ). In
Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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trophoblast differentiation into mature cells both in successful and diseased pregnancy. Recent literature has covered the transcription factors networks sustaining trophoblast cell identity ( Papuchova & Latos 2022 ). In this review, we will present
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activator of transcription 3 (STAT3) and ERα in the nucleus during the late pre-implantation stage of pregnancy. We provide evidence that SOS1 is a coactivator of STAT3 on account of the presence of acetyl CoA binding motifs and a repressor of ERα by virtue
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Introduction There is abundant in vivo and in vitro evidence that progesterone and estrogen are key factors in regulating myometrial contractility associated with the maintenance of pregnancy and the onset of labor across species