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James W Antoon Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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William D Meacham Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Melyssa R Bratton Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Evelyn M Slaughter Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Lyndsay V Rhodes Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Hasina B Ashe Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Thomas E Wiese Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Matthew E Burow Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Barbara S Beckman Tulane Department of Pharmacology, Section of Hematology and Medical Oncology, Department of Pharmacy, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-83, New Orleans, Louisiana 70112, USA

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Introduction Breast cancer is the second leading cause of cancer death in women today, with one in eight women diagnosed in her lifetime, and drug resistance remains the leading cause of breast cancer treatment failure. Approximately 70% of breast

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0116
Volume/Issue:
Volume 46: Issue 3
Free access
Ayse Basak Engin Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey

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Atilla Engin Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey

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Ipek Isik Gonul Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey

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and intermuscular depots in obese premenopausal women ( Janiszewski et al. 2010 ). Postmenopausal patients with high visceral fat area have significantly shorter distant disease-free survival than premenopausal patients in breast cancer series

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0252
Volume/Issue:
Volume 62: Issue 3
Free access
Federica Morani Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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Suratchanee Phadngam Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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Carlo Follo Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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Rossella Titone Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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Gianluca Aimaretti Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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Alessandra Galetto Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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Oscar Alabiso Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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Ciro Isidoro Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences

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proliferating cancer cells, glucose is preferentially converted into lactate despite the presence of oxygen and functional mitochondria. This aberrant metabolism of glucose, known as the Warburg effect or aerobic glycolysis, is much less convenient in terms of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0118
Volume/Issue:
Volume 53: Issue 2
Free access
Chen-Lin Hsieh Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Changmeng Cai Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Ahmed Giwa Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Aaronica Bivins Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Shao-Yong Chen Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Dina Sabry Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Kumara Govardhan Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Lirim Shemshedini Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA

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Introduction Prostate cancer is an epithelial-derived cancer ( Cussenot et al . 1994 ) that involves the action of androgens and androgen receptor (AR), a ligand-dependent transcription factor ( Chang et al . 1988 ). This liganded AR is essential

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-07-0158
Volume/Issue:
Volume 41: Issue 1
Free access
Niamh Cosgrave
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Arnold D K Hill
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Leonie S Young
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undetectable in most healthy, differentiated adult tissues but it is prominently expressed in transformed cell lines and most common human cancers ( Ambrosini et al. 1997 , Adida et al. 1998 b , Chiou et al. 2003 ). Present studies show that the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02118
Volume/Issue:
Volume 37: Issue 3
Free access
You-Hong Cheng
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Hiroki Utsunomiya Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Suite 4-131, Chicago, Illinois 60611-3095, USA

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Mary Ellen Pavone
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Ping Yin
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Serdar E Bulun
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Introduction Endometrial cancer is the most common gynecologic malignancy. It accounts for 6% of all cancers in women and is the eighth most common cause of cancer-related death in the United States ( Obel et al . 2006 ). According to the American

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0064
Volume/Issue:
Volume 46: Issue 2
Free access
Caroline H Diep Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Andrea R Daniel Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Laura J Mauro Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Todd P Knutson Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Carol A Lange Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division
Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Introduction Progesterone and progesterone receptors (PRs) are increasingly gaining attention for their emerging role as critical regulators of breast and gynecological cancers. With this newfound spotlight on PR action, there is an urgent need to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0252
Volume/Issue:
Volume 54: Issue 2
Free access
Matias Knuuttila Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, University of Turku, Turku, Finland

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Esa Hämäläinen Department of Clinical Chemistry and HUSLAB, Helsinki University and Helsinki University Hospital, HUSLAB, Helsinki, Finland

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Matti Poutanen Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, University of Turku, Turku, Finland
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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, supporting the hypothesis that these steroids are originating from adrenal precursors ( Turcu et al. 2016 ). Interestingly, remarkable levels of 11KT and 11KDHT were also detected in prostate tissue and plasma of prostate cancer (PCa) patients by LC

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0150
Volume/Issue:
Volume 62: Issue 4
Free access
Marika H Tesselaar Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands

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Johannes W Smit Internal Medicine, Division of Endocrinology Radboud University Medical Center, Nijmegen, The Netherlands

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James Nagarajah Radiology & Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Romana T Netea-Maier Internal Medicine, Division of Endocrinology Radboud University Medical Center, Nijmegen, The Netherlands

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Theo S Plantinga Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands

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Introduction Non-medullary thyroid cancer (TC) is the most frequent endocrine tumor accounting for 90% of all endocrine cancer cases. Several histological TC subtypes are distinguished as papillary TC (PTC) as the most frequent, followed by

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-17-0134
Volume/Issue:
Volume 59: Issue 4
Free access
Soojin Kim Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Daksh Thaper Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Samir Bidnur Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Paul Toren Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Shusuke Akamatsu Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Jennifer L Bishop Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Colin Colins Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Sepideh Vahid Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Amina Zoubeidi Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Introduction Prostate cancer (PCa) is the most commonly diagnosed and the third leading cause of cancer mortality among Canadian men ( CCSsACoC 2017 ). Initially, most cases of prostate adenocarcinoma are hormone driven and respond to androgen

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0226
Volume/Issue:
Volume 63: Issue 1
Free access