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Adrien Georges CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France
CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France

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Aurelie Auguste CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France
CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France

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Laurianne Bessière CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France
CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France

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Anne Vanet CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France
CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France

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Anne-Laure Todeschini CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France
CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France

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Reiner A Veitia CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France
CNRS UMR 7592, Université Paris Diderot, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France

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/differentiation encode factors involved in β-catenin signaling. In particular, WNT4 and RSPO1, two secreted positive effectors of β-catenin signaling and of β-catenin expression, are required for the development of functional ovaries ( Vainio et al . 1999 , Chassot et

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0159
Volume/Issue:
Volume 52: Issue 1
Free access
Lian Liu Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Singareddy Rajareddy Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Pradeep Reddy Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Krishna Jagarlamudi Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Chun Du Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Yan Shen Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Yongzhi Guo Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Karin Boman Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Eva Lundin Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Ulrika Ottander Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Gunnar Selstam Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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Kui Liu Departments of Medical Biochemistry and Biophysics,
Radiation Sciences,
Medical Biosciences/Pathology,
Clinical Science/Obstetrics and Gynecology,
Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
Qilu Hospital, Shandong University, Jinan, 250012 Shandong, China

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recognized as a critical downstream element of the PI3K and the Wnt signaling pathways ( Cross et al. 1995 , Nusse 1997 , Srivastava & Pandey 1998 ). Moreover, GSK-3β has been shown to regulate cyclin D1 proteolysis and subcellular localization in mouse

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02027
Volume/Issue:
Volume 38: Issue 1
Free access
Clara V Alvarez Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Montserrat Garcia-Lavandeira Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Maria E R Garcia-Rendueles Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Esther Diaz-Rodriguez Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Angela R Garcia-Rendueles Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Sihara Perez-Romero Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Tania Vila Vila Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Joana S Rodrigues Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Pamela V Lear Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain
Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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Susana B Bravo Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias (CIMUS‐IDIS), Department of Cardiology, Department of Physiology, University of Santiago de Compostela (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain

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+) supply. When the blood in these capillaries becomes depleted of oxygen, Wnt ligands are released inducing a response that mobilizes ASCs through bCat activation (see below). Figure 2 The adult SC niche. ASCs are organized in a compact structure supported

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0072
Volume/Issue:
Volume 49: Issue 2
Free access
Ruifeng Shi Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China

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Jing Cen Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Gunilla T Westermark Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Sheng Zhao Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, China

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Nils Welsh Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Zilin Sun Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China

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Joey Lau Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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. One recent study carried out in mouse focusing on osteogenesis has identified that ITGA11 is an osteolectin receptor, and the Wnt pathway could be activated by the binding of osteolectin to the ITGA11 ( Shen et al. 2019 ). The expression of ITGA11

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0066
Volume/Issue:
Volume 71: Issue 1
Open access
Yewei Xing
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C Richard Parker Departments of Physiology and Surgery, Department of Obstetrics and Gynecology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA

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Michael Edwards
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William E Rainey
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-Hydroxytryptamine (serotonin) receptor 2B HOPX 0.33±0.14 0.0431 NM_032495.4 HOP homeobox CPB1 0.37±0.06 0.0084 NM_001871.2 Carboxypeptidase B1 C7 0.38±0.01 0.0001 NM_000587.2 Complement component 7 WISP2 0.38±0.08 0.0166 NM_003881.2 WNT1-inducible signaling pathway

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0006
Volume/Issue:
Volume 45: Issue 1
Free access
Barry V L Potter Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Oxford, UK

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of compounds continue to illustrate the potential of the aryl sulphamate pharmacophore. Wnt signalling pathway activity While STS is now well established as a therapeutic target for oestrogen-dependent diseases, potential wider cellular

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0045
Volume/Issue:
Volume 61: Issue 2
Free access
L A Bach Department of Medicine (Alfred), Monash University, Melbourne, Australia
Department of Endocrinology and Diabetes, Alfred Hospital, Melbourne, Australia

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et al . 2013 ). IGFBP-2 increased cancer cell proliferation, survival and migration/invasion via mechanisms involving integrins and other pathways including Wnt ( Mehrian-Shai et al . 2007 , Holmes et al . 2012 , Baxter 2014 , Russo et al . 2015

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-17-0254
Volume/Issue:
Volume 61: Issue 1
Free access
Peng Zhang Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou, China

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Sheng Wang Emergency Department, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China

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Liang Wang Department of Radiology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China

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Bing Chen Shan Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou, China

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Hui Zhang Osteoprosis Institute of Soochow University, Suzhou, China

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Fan Yang Osteoprosis Institute of Soochow University, Suzhou, China

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Zhi Qiang Zhou Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou, China

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Xiao Wang Osteoprosis Institute of Soochow University, Suzhou, China

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Ye Yuan Osteoprosis Institute of Soochow University, Suzhou, China

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You Jia Xu Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou, China
Osteoprosis Institute of Soochow University, Suzhou, China

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upregulation of ROS levels competitively inhibits the downstream Tcf/Lef transcription of β-catenin, affects osteogenesis through Wnt signaling and results in decreased bone mass ( Almeida et al . 2007 ). We also found that osteoclast activity, bone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0301
Volume/Issue:
Volume 60: Issue 4
Free access
Erik Elebring Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Anna Casselbrant Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Sara M T Persson Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Lars Fändriks Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, Gothenburg, Sweden

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Ville Wallenius Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, Gothenburg, Sweden

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. Isolated crypts were seeded, embedded in Matrigel (Corning) in 24-well plates and cultured with Wnt3A-supplemented expansion media (IntestiCult Organoid Growth Media (STEMCELLS, Vancouver, Canada) with 10 μM Y-27632 (Sigma-Aldrich) and 0.1% gentamycin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0115
Volume/Issue:
Volume 70: Issue 4
Open access
Xiaoxia Che Department of Obstetrics & Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China

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Fangfang Jian Department of Obstetrics & Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Chen Chen Department of Obstetrics & Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Chang Liu Department of Obstetrics & Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Gedan Liu Department of Obstetrics & Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Weiwei Feng Department of Obstetrics & Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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. Ba et al. (2017) showed that miR-27a promoted the proliferation and invasion of colon cancer cells by targeting SFRP1 through the Wnt/β-catenin signaling pathway. Similarly, a study by Sun et al. (2015) showed that miR-27a, which was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0159
Volume/Issue:
Volume 64: Issue 1
Restricted access