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Philippe Huber Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Christine Mallet Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Elodie Faure Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Christine Rampon Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Marie-Hélène Prandini Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Olivier Féraud Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Stéphanie Bouillot Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Isabelle Vilgrain Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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. Using VE-cadherin-chloramphenicol acetyl transferase (CAT) transgenic mice, we demonstrated that regulation occurred at the level of transcription. The dexamethasone-induced transcriptional reduction was specific to the adrenal gland, thereby

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01641
Volume/Issue:
Volume 34: Issue 1
Free access
Sue Ing Quek Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Republic of Singapore 117543

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Woon Khiong Chan Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Republic of Singapore 117543

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( Jefcoate et al . 1987 ). cAMP also activates the transcription of steroid hydroxylases, leading to a sustained maintenance of steroidogenesis on a longer term basis ( John et al . 1986 ). The transcriptional regulation of mammalian CYP11A1 , including

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0029
Volume/Issue:
Volume 43: Issue 3
Free access
Thomas Ohnesorg
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Brigitte Keller
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Martin Hrabé de Angelis
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Jerzy Adamski
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. In order to gain further insight into its in vivo functionality and due to possible differences between the human and murine enzymes, we performed a detailed analysis of the transcriptional regulation of the human and murine homologs of HSD17B7. The

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02043
Volume/Issue:
Volume 37: Issue 1
Free access
Michael E Baker
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Gary Hardiman Department of Medicine, CSRC and BIMRC, Department of Medicine, University of California San Diego, 9500 Gilman Drive 0605, La Jolla, California 92093-0605, USA
Department of Medicine, CSRC and BIMRC, Department of Medicine, University of California San Diego, 9500 Gilman Drive 0605, La Jolla, California 92093-0605, USA

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. 2004 , Zhou & Cidlowski 2005 , Odermatt & Gumy 2008 , McEwen 2012 ). Although these actions are mediated primarily by the glucocorticoid receptor (GR); in some cells, cortisol is a transcriptional activator of the mineralocorticoid receptor (MR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0219
Volume/Issue:
Volume 52: Issue 3
Free access
M-B Debril Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, BP10142, 67404 Illkirch Cedex, France
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland

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L Dubuquoy Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, BP10142, 67404 Illkirch Cedex, France
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland

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J-N Feige Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, BP10142, 67404 Illkirch Cedex, France
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland

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W Wahli Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, BP10142, 67404 Illkirch Cedex, France
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland

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B Desvergne Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, BP10142, 67404 Illkirch Cedex, France
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland

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J Auwerx Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, BP10142, 67404 Illkirch Cedex, France
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland

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L Gelman Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS / INSERM / ULP, BP10142, 67404 Illkirch Cedex, France
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland

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Introduction In eukaryotic cells, the structure of chromatin has been shown to repress mainly gene activation, and both remodeling and repositioning of nucleosomes are necessary to allow binding of transcription factors and the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01856
Volume/Issue:
Volume 35: Issue 3
Free access
Gregory S Y Ong Cardiovascular Endocrinology Laboratory, Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

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( Milliez et al . 2005 ). The MR can change cell function through multiple means. Edelman first proposed that aldosterone modifies sodium transport via gene transcription ( Edelman et al . 1963 ), a mechanism recently confirmed as critical for life

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0318
Volume/Issue:
Volume 58: Issue 1
Free access
Anne-Marie O’Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), Dorothy Hodgkin Building, Whitson Street, University of Bristol, Bristol BS1 3NY, UK

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Stephen J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), Dorothy Hodgkin Building, Whitson Street, University of Bristol, Bristol BS1 3NY, UK

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Gillian M Howell Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), Dorothy Hodgkin Building, Whitson Street, University of Bristol, Bristol BS1 3NY, UK

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tract and the dorsal raphe nucleus – also express APJR mRNA ( De Mota et al. 2000 ). The molecular basis for the regulation of APJR gene transcription is not known. There is evidence however, to indicate that the steady-state levels of the gene

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01927
Volume/Issue:
Volume 36: Issue 1
Free access
Jin Bai Department of Obstetrics and Gynecology, University of California, Irvine, California, USA

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Thomas J Lechuga Department of Biology, San Bernardino Valley College, San Bernardino, California, USA

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Joshua Makhoul Department of Obstetrics and Gynecology, University of California, Irvine, California, USA

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Hao Yan Department of Obstetrics and Gynecology, University of California, Irvine, California, USA

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Carol Major Department of Obstetrics and Gynecology, University of California, Irvine, California, USA

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Afshan Hameed Department of Obstetrics and Gynecology, University of California, Irvine, California, USA

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Dong-bao Chen Department of Obstetrics and Gynecology, University of California, Irvine, California, USA

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vitro by stimulating specific-ER dependent upregulation of CBS transcription, involving ERα and ERβ ( Lechuga et al. 2019 a , b ). However, E 2 β also stimulates CSE expression in these ovine UA cell models, contrasting to in vivo conditions

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0175
Volume/Issue:
Volume 70: Issue 2
Restricted access
SA Akker
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PJ Smith
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SL Chew
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The mammalian nucleus has considerable control over nascent transcripts. The basic mechanisms of post-transcriptional processing are well understood and recently some of the principles underlying the regulation of nuclear processing events have been elucidated. Here we review the recent progress in identification of signalling pathways that modulate the action of key RNA-binding proteins which regulate splicing, and the mechanisms of action of the C-terminal domain of RNA polymerase II that co-ordinate transcription with nuclear mRNA processing events.

Article Type:
Other
DOI:
https://doi.org/10.1677/jme.0.0270123
Volume/Issue:
Volume 27: Issue 2
Free access
D Bouton INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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H Escriva INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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R L de Mendonça INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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C Glineur INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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B Bertin INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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C Noël INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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M Robinson-Rechavi INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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A de Groot INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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J Cornette INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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V Laudet INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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R J Pierce INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
CNRS UMR 49, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364-Lyon, France
INSERM U 545 Institut Pasteur, 1 rue du Professeur Calmette, 59019-Lille, France
Laboratoire d’Écologie Microbienne de la Rhizosphère (LEMiR), Département d’Écophysiologie Végétale et de Microbiologie (DEVM), CEA Cadarache, 13108 Saint Paul Lez Durance, France

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), but transactivation of transcription by T. cystophora RXR in the presence of the ligand was not demonstrated. Among the non-moulting triploblastic invertebrates, the Lophotrochozoa ( Aguinaldo et al. 1997 ), RXR family members have been

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01766
Volume/Issue:
Volume 34: Issue 2
Free access