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René Lafont Biophytis, Sorbonne Université – BC9, Paris, France
Sorbonne Université, CNRS -Institut de Biologie Paris Seine (BIOSIPE), Paris, France

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Maria Serova Biophytis, Sorbonne Université – BC9, Paris, France

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Blaise Didry-Barca Biophytis, Sorbonne Université – BC9, Paris, France

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Sophie Raynal Biophytis, Sorbonne Université – BC9, Paris, France

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Louis Guibout Biophytis, Sorbonne Université – BC9, Paris, France

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Laurence Dinan Biophytis, Sorbonne Université – BC9, Paris, France

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Stanislas Veillet Biophytis, Sorbonne Université – BC9, Paris, France

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Mathilde Latil Biophytis, Sorbonne Université – BC9, Paris, France

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Waly Dioh Biophytis, Sorbonne Université – BC9, Paris, France

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Pierre J Dilda Biophytis, Sorbonne Université – BC9, Paris, France

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Introduction Steroids in animal and plant kingdoms Steroid hormones are (chole)sterol derivatives widespread in animals and plants, where they are involved in the control of many physiological processes. They include, for example

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JME-21-0033
Volume/Issue:
Volume 68: Issue 2
Restricted access
Francesco J DeMayo Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

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John P Lydon Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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cognate receptors for other steroid hormones (including estrogen) as well as for retinoids, prostanoids, thyroid hormone, and vitamin D3 ( Tsai & O’Malley 1994 , Mangelsdorf et al . 1995 ). As a nuclear receptor superfamily member, the PGR is modular in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-19-0212
Volume/Issue:
Volume 65: Issue 1
Free access
Eva A Rog-Zielinska Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Rachel V Richardson Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Martin A Denvir Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Karen E Chapman Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Introduction Glucocorticoids are steroid hormones produced by the adrenal cortex. They regulate stress responses and exert potent immunomodulatory effects in adults ( McEwen 1997 ) and are essential for the transition from foetal to neonatal life

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0204
Volume/Issue:
Volume 52: Issue 2
Free access
Yasmine Hachemi Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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Anna E Rapp Institute of Orthopaedic Research and Biomechanics, Ulm University Medical Centre, Ulm, Germany

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Ann-Kristin Picke Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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Gilbert Weidinger Institute of Biochemistry and Molecular Biology, Ulm University, Ulm, Germany

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Anita Ignatius Institute of Orthopaedic Research and Biomechanics, Ulm University Medical Centre, Ulm, Germany

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Jan Tuckermann Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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(CRF), which in turn acts on the pituitary, stimulating its release of adrenocorticotropic hormone (ACTH). ACTH acts on the zona fasciculata of the adrenal cortex for the release of GCs, which belong to the steroid class of hormones. Cortisol as the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0024
Volume/Issue:
Volume 61: Issue 1
Open access
Excel Rio S Maylem Department of Animal and Food Sciences, Oklahoma State University, Stillwater, Oklahoma, USA

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Leon J Spicer Department of Animal and Food Sciences, Oklahoma State University, Stillwater, Oklahoma, USA

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Isadora Batalha Department of Agriculture, Veterinary, and Rangeland Sciences, University of Nevada, Reno, Nevada, USA

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Luis F Schutz Department of Agriculture, Veterinary, and Rangeland Sciences, University of Nevada, Reno, Nevada, USA

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for expression of FBN1 mRNA in TC. The effects of asprosin on steroid production and proliferation of TC were also evaluated. Materials and methods Reagents and hormones Reagents used for cell culture were: Dulbecco’s modified Eagle

Article Type:
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Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JME-20-0218
Volume/Issue:
Volume 66: Issue 1
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Rosalia C M Simmen
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Melissa E Heard
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Angela M Simmen Department of Physiology and Biophysics, Department of Obstetrics and Gynecology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA

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Maria Theresa M Montales
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Meera Marji
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Samantha Scanlon
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John Mark P Pabona Department of Physiology and Biophysics, Department of Obstetrics and Gynecology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA

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, including endometrial and cervical carcinoma, endometriosis, and leiomyoma, may arise post-puberty to further contribute to infertility. The steroid hormones estrogen and progesterone, working through their cognate nuclear receptors (estrogen receptor 1 (ESR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0310
Volume/Issue:
Volume 54: Issue 2
Free access
Isabelle Durrer Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Daniel Ackermann Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Rahel Klossner Department of Nephrology and Hypertension University of Bern, Berne, Switzerland
Department of Internal Medicine, Sonnenhof, Lindenhofgruppe, Berne, Switzerland

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Michael Grössl Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Clarissa Vögel Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Therina Du Toit Department for BioMedical Research University of Bern, Berne, Switzerland

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Bruno Vogt Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Heidi Jamin Department of Nephrology and Hypertension University of Bern, Berne, Switzerland
Department for BioMedical Research University of Bern, Berne, Switzerland

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Markus G Mohaupt Department of Internal Medicine, Sonnenhof, Lindenhofgruppe, Berne, Switzerland
Department for BioMedical Research University of Bern, Berne, Switzerland

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Carine Gennari-Moser Department of Nephrology and Hypertension University of Bern, Berne, Switzerland
Department for BioMedical Research University of Bern, Berne, Switzerland

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added with the steroid hormone substrates progesterone, DOC, corticosterone or 18-OH-corticosterone at a concentration of 10 −6 M and with or without AngII (10 −6 M). After 24 h, the supernatant was collected for LC-MS analysis and total RNA extraction

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0100
Volume/Issue:
Volume 72: Issue 3
Open access
Sue Ing Quek Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Republic of Singapore 117543

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Woon Khiong Chan Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Republic of Singapore 117543

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Introduction The biosynthesis of active steroid hormones from cholesterol in the adrenal cortex and the gonads involves five distinct steroid hydroxylases that belong to the cytochrome P450 gene family and two hydroxysteroid dehydrogenases ( Payne

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0029
Volume/Issue:
Volume 43: Issue 3
Free access
Douglas A Gibson Medical Research Council Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Ioannis Simitsidellis Medical Research Council Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philippa T K Saunders Medical Research Council Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Introduction The human endometrium is a complex multicellular tissue that undergoes cyclical remodelling in response to fluctuating levels of sex steroid hormones produced by the ovaries ( Critchley & Saunders 2009 ). The endometrium has

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0027
Volume/Issue:
Volume 57: Issue 1
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Mellodee M White Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Irene Sheffer Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Jennifer Teeter Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Ede Marie Apostolakis Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Introduction The ovarian steroid hormone progesterone (Prog) is important for female reproductive functions, including ovulation, uterine and mammary gland development, maintenance of pregnancy, and sexual behavior ( Clarke

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02058
Volume/Issue:
Volume 38: Issue 1
Free access