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Raffaella Maria Gadaleta Division of Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, W12 0NN, UK

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Luca Magnani Division of Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, W12 0NN, UK

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Introduction/overview Nuclear receptors (NRs) are evolutionarily related DNA-binding transcription factors (TFs) ( Gronemeyer et al . 2004 , Chambon 2005 , Evans 2005 ). They regulate many aspects of mammalian physiology, including metabolism

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0170
Volume/Issue:
Volume 52: Issue 2
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Diego Ferone Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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Federico Gatto Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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Marica Arvigo Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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Eugenia Resmini Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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Mara Boschetti Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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Claudia Teti Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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Daniela Esposito Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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Francesco Minuto Department of Endocrinological & Medical Sciences (DiSEM) and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

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actions of SRIF and DA are mediated by specific G-protein-coupled receptors (GPCR) that are present on the cells of both the normal gland and of the pituitary adenomas: SRIF receptor (SSR) subtypes 1, 2, 3 and 5 (sst 1–5 ; Miller et al . 1995 , Hofland

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0162
Volume/Issue:
Volume 42: Issue 5
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Daniel Cuevas-Ramos
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Maria Fleseriu Department of Medicine, Northwest Pituitary Center and Departments of Medicine and Neurological Surgery, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

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-protein-coupled somatostatin receptors (SSTR), SSTR1–SSTR5, and the description of the downstream signaling and function highlighted both hormone secretion inhibitory activity and an antiproliferative role. Furthermore, identification of key SST molecular structural

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0011
Volume/Issue:
Volume 52: Issue 3
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Carrie S Shemanko Department of Biological Sciences, Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada

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the metastatic process of breast cancer. The intricacy of these conflicting observations intriguingly lies somewhere in the spectrum of signaling pathways, involving multiple receptor isoforms and the interaction of the breast cancer cells with the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0150
Volume/Issue:
Volume 57: Issue 4
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Jong-Ik Hwang Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Seongsik Yun Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Mi Jin Moon Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Cho Rong Park Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Jae Young Seong Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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. 2003 , Perry et al . 2007 ). The physiological activities of GLP1 occur by interaction with the GLP1 receptor (GLP1R), which is expressed in pancreatic islets, brain, heart, kidney, and the gastrointestinal tract ( Graziano et al . 1993 , Wei

Article Type:
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DOI:
https://doi.org/10.1530/JME-13-0137
Volume/Issue:
Volume 52: Issue 3
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Pitchai Balakumar
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Gowraganahalli Jagadeesh Pharmacology Unit, Division of Cardiovascular and Renal Products, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia

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of Ang II receptor blockers have demonstrated the existence of two major subtypes of Ang II receptors, AT 1 and AT 2 . Both receptors belong to the seven-transmembrane receptor or G protein-coupled receptor (GPCR) superfamily. Since the first

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https://doi.org/10.1530/JME-14-0125
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Volume 53: Issue 2
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Rosalia C M Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Angela S Kelley Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, Michigan, USA

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Estrogens are key mediators of endometrial homeostasis; hence, any dysregulation in their synthesis, metabolism, and/or activities irrefutably leads to a broad range of endometrial pathologies. Two major estrogen receptor proteins, estrogen

Article Type:
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https://doi.org/10.1530/JME-16-0080
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Volume 57: Issue 2
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Ting-Ting Zhou Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Fei Ma School of Pharmacy, East China University of Science and Technology, Shanghai, China

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Xiao-Fan Shi Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xin Xu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Te Du Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xiao-Dan Guo Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Gai-Hong Wang Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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Liang Yu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Vatcharin Rukachaisirikul Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand

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Li-Hong Hu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Jing Chen Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xu Shen Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China
Key Laboratory of Drug Target and Drug for Degenerative Disease, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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disturbances, edema, weight gain and lactic acidosis ( Moller 2001 , Xu et al . 2014 ). For example, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are newly injectable peptide drugs used for the treatment of hyperglycemia ( Scheen 2016 ). They are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0121
Volume/Issue:
Volume 59: Issue 2
Free access
Ricardo Núñez Miguel FIRS Laboratories, RSR Ltd, Cardiff, UK

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Jane Sanders FIRS Laboratories, RSR Ltd, Cardiff, UK

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Jadwiga Furmaniak FIRS Laboratories, RSR Ltd, Cardiff, UK

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Bernard Rees Smith FIRS Laboratories, RSR Ltd, Cardiff, UK

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-linked sites are expendable for hCG function ( Wu et al . 1994 ), whereas N-linked glycosylations play a role in signal transduction but do not affect receptor-binding affinity ( Moyle et al . 1975 ). Deglycosylated hCG forms a tight complex with its receptor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0169
Volume/Issue:
Volume 58: Issue 1
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A R Rodrigues Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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D Sousa Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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H Almeida Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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A M Gouveia Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Department of Experimental Biology, Instituto de Biologia Molecular e Celular (IBMC), IPATIMUP, Faculty of Nutrition and Food Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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Introduction Melanocortin receptors (MCRs) have received increased attention by the pharmaceutical industry due to their involvement in pigmentation, steroidogenesis, energy homoeostasis, sexual function, inflammation and exocrine gland regulation

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0055
Volume/Issue:
Volume 51: Issue 2
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