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Riccarda Granata Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism
Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism

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Alessandra Baragli Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism
Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism

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Fabio Settanni Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism
Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism

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Francesca Scarlatti Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism
Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism

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Ezio Ghigo Laboratory of Molecular, Division of Endocrinology, Cellular Endocrinology and Metabolism

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Li HY Jiang QY Zou XT 2009 Is GPR39 the natural receptor of obestatin? Peptides 30 431 – 438 . doi:10.1016/j.peptides.2008.09.022 . Drucker DJ 2006 The biology of incretin hormones . Cell Metabolism 3 153 – 165 . doi:10

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0019
Volume/Issue:
Volume 45: Issue 3
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Guojun Shi Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Chen Sun Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Weiqiong Gu Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Minglan Yang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Xiaofang Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Nan Zhai Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Yan Lu Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Zhijian Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Peishun Shou Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Zhiguo Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Guang Ning Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

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Tsujimoto G 2005 Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 . Nature Medicine 11 90 – 94 . ( doi:10.1038/nm1168 ). Hong YH Nishimura Y Hishikawa D Tsuzuki H Miyahara H Gotoh C Choi KC Feng

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0065
Volume/Issue:
Volume 53: Issue 3
Free access
Sofia A Rahman Genetics and Genomic Medicine, Department of Paediatric Endocrinology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Azizun Nessa Genetics and Genomic Medicine, Department of Paediatric Endocrinology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Khalid Hussain Genetics and Genomic Medicine, Department of Paediatric Endocrinology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Genetics and Genomic Medicine, Department of Paediatric Endocrinology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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. ( doi:10.1074/jbc.274.29.20628 ). Shi Y Avatapalle HB Skae MS Padidela R Newbould M Rigby L Flanagan SE Ellard S Rahier J Clayton PE 2015 Increased plasma incretin concentrations identifies a subset of patients with persistent

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0016
Volume/Issue:
Volume 54: Issue 2
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Jianling Xie Department of Cell Physiology and Pharmacology, University of Leicester, Henry Wellcome Building, University Road, Leicester LE1 9HN, UK

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Norhan M El Sayed Department of Cell Physiology and Pharmacology, University of Leicester, Henry Wellcome Building, University Road, Leicester LE1 9HN, UK

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Cheng Qi Department of Cell Physiology and Pharmacology, University of Leicester, Henry Wellcome Building, University Road, Leicester LE1 9HN, UK

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Xuechan Zhao Department of Cell Physiology and Pharmacology, University of Leicester, Henry Wellcome Building, University Road, Leicester LE1 9HN, UK

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Claire E Moore Department of Cell Physiology and Pharmacology, University of Leicester, Henry Wellcome Building, University Road, Leicester LE1 9HN, UK

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Terence P Herbert Department of Cell Physiology and Pharmacology, University of Leicester, Henry Wellcome Building, University Road, Leicester LE1 9HN, UK

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.2337/diabetes.53.6.1517 ). Kwon G Marshall CA Pappan KL Remedi MS McDaniel ML 2004 Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets . Diabetes 53 ( Suppl 3 ) S225 – S232

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DOI:
https://doi.org/10.1530/JME-13-0200
Volume/Issue:
Volume 53: Issue 1
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Eva Tudurí Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Monica Imbernon Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain

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Rene Javier Hernández-Bautista Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain

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Marta Tojo Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain

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Johan Fernø Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway

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Carlos Diéguez Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain

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Rubén Nogueiras Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain

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Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice . Diabetologia 59 2674 – 2685 . ( doi:10.1007/s00125-016-4108-z ) Meadows

Article Type:
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DOI:
https://doi.org/10.1530/JME-16-0253
Volume/Issue:
Volume 58: Issue 3
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Dennis Brüning Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany

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Kirstin Reckers Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany

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Peter Drain Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Ingo Rustenbeck Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany

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M Yokoi N Minami K Nakayama Y Harada K Hastoy B Wu X Takahashi H 2014 Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion . Cell Reports 9 661 – 673

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https://doi.org/10.1530/JME-17-0063
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Volume 59: Issue 3
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Cristina Velasco Departamento de Bioloxía Funcional e Ciencias da Saúde, Laboratorio de Fisioloxía Animal, Facultade de Bioloxía and Centro de Investigación Mariña, Universidade de Vigo, Vigo, Spain

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Sara Comesaña Departamento de Bioloxía Funcional e Ciencias da Saúde, Laboratorio de Fisioloxía Animal, Facultade de Bioloxía and Centro de Investigación Mariña, Universidade de Vigo, Vigo, Spain

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Marta Conde-Sieira Departamento de Bioloxía Funcional e Ciencias da Saúde, Laboratorio de Fisioloxía Animal, Facultade de Bioloxía and Centro de Investigación Mariña, Universidade de Vigo, Vigo, Spain

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Jesús M Míguez Departamento de Bioloxía Funcional e Ciencias da Saúde, Laboratorio de Fisioloxía Animal, Facultade de Bioloxía and Centro de Investigación Mariña, Universidade de Vigo, Vigo, Spain

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José L Soengas Departamento de Bioloxía Funcional e Ciencias da Saúde, Laboratorio de Fisioloxía Animal, Facultade de Bioloxía and Centro de Investigación Mariña, Universidade de Vigo, Vigo, Spain

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different. Thus, in fish, GLP-1 stimulates gluconeogenesis and glycogenolysis ( Mommsen et al. 1987 , Mojsov 2000 , Irwin & Mojsov 2018 ), thereby increasing glycaemia, whereas in mammals it stimulates insulin release (incretin) and slows gastric

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https://doi.org/10.1530/JME-18-0212
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Volume 62: Issue 3
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Kira Meyerovich ULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Fernanda Ortis Department of Cell and Developmental Biology, Universidade de São Paulo, São Paulo, Brazil

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Florent Allagnat Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

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Alessandra K Cardozo ULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), Brussels, Belgium

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colitis . American Journal of Pathology 174 1786 – 1798 . ( doi:10.2353/ajpath.2009.080864 ) Nauck M 2016 Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and

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https://doi.org/10.1530/JME-15-0306
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Ting-Ting Zhou Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Fei Ma School of Pharmacy, East China University of Science and Technology, Shanghai, China

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Xiao-Fan Shi Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xin Xu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Te Du Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xiao-Dan Guo Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Gai-Hong Wang Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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Liang Yu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Vatcharin Rukachaisirikul Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand

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Li-Hong Hu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Jing Chen Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xu Shen Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China
Key Laboratory of Drug Target and Drug for Degenerative Disease, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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-14.2015 ) 10.1523/JNEUROSCI.3933-14.2015 Lamont BJ Andrikopoulos S 2014 Hope and fear for new classes of type 2 diabetes drugs: is there preclinical evidence that incretin-based therapies alter pancreatic morphology? Journal of Endocrinology

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https://doi.org/10.1530/JME-17-0121
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Volume 59: Issue 2
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Amanda M Ackermann Departments of Medicine,
Molecular Physiology and Biophysics and
Program in Developmental Biology, Vanderbilt University Medical Center, 2220 Pierce Avenue 746 PRB, Nashville, Tennessee 37232, USA

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Maureen Gannon Departments of Medicine,
Molecular Physiology and Biophysics and
Program in Developmental Biology, Vanderbilt University Medical Center, 2220 Pierce Avenue 746 PRB, Nashville, Tennessee 37232, USA

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)     Incretins GLP-1R −/− ↔β cell mass Ling et al. (2001) GIPR −/− ↑ β cell mass Pamir et al. (2003)     Gastrin Rip-Gastrin Tg ↔β cell mass Wang et al. (1993) Gastrin −/− ↔β cell mass, ↔β cell proliferation Boushey et al. (2003) Cell signaling proteins

Article Type:
Review Article
DOI:
https://doi.org/10.1677/JME-06-0053
Volume/Issue:
Volume 38: Issue 2
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