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Luke A Noon
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Artem Bakmanidis
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Peter J O’Shaughnessy
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Peter J King
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and neonatal mouse testis. Endocrinology 144 3279 –3284. Reynolds K , Zimmer AM & Zimmer A 1996 Regulation of RAR beta 2 mRNA expression: evidence for an inhibitory peptide encoded in the 5′-untranslated region

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Kenneth R McGaffin Vincent T Lombardi Cancer Center, Department of Biochemistry and Molecular Biology, 3900 Reservoir Road, Georgetown University Medical Center, Washington, DC 20007

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Susan A Chrysogelos Vincent T Lombardi Cancer Center, Department of Biochemistry and Molecular Biology, 3900 Reservoir Road, Georgetown University Medical Center, Washington, DC 20007

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against the corresponding forms of retinoic acid receptor (RAR) were obtained from Dr. Wayne Vedeckis (Louisiana State University Medical Center, New Orleans, LA, USA). In vitro DNAse I footprinting Crude nuclear

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H K Kinyamu Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, PO Box 12233 (MD E4-06), Research Triangle Park, North Carolina 27709, USA

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J Chen Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, PO Box 12233 (MD E4-06), Research Triangle Park, North Carolina 27709, USA

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T K Archer Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, PO Box 12233 (MD E4-06), Research Triangle Park, North Carolina 27709, USA

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glucocorticoid (GR), estrogen (ER), progesterone (PR), androgen (AR), thyroid (TR), retinoic acid (RAR) and vitamin D (VDR) receptors – undergo ligand-dependent proteasome-mediated proteolysis provide a direct link between NR-mediated gene transcription and the

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Nikolaos Volakakis
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Michal Malewicz
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Banafsheh Kadkhodai
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Thomas Perlmann
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Gerard Benoit
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resemble the regulation of retinoic acid receptor (RAR), the estrogen receptor, and the progesterone receptor ( Lonard et al. 2000 , Shen et al. 2001 ), which after ligand-induced activation, are rapidly degraded via the ubiquitin/proteasome pathway

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R F Chun Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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M Gacad Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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L Nguyen Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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M Hewison Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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J S Adams Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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interaction with the retinoid acid receptor (RAR; Liu et al. 1998 ). Based on these observations, they concluded that the potentiation of VDR responsiveness by BAG-1L involved several regions including the hsc70 ATPase-interacting BAG domain which is common

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Lacey M Litchfield Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA

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Carolyn M Klinge Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA

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et al . 2012 ). This indicates a potential feed-forward loop, as treatment with RA may increase both the expression and activation of COUP-TFII, with downstream effects on RAR. Figure 3 Regulation of COUP-TFII expression. COUP-TFII expression has been

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Margaret Warner Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA

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Xiaotang Fan Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, People’s Republic of China

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Anders Strom Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA

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Wanfu Wu Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA

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Jan-Åke Gustafsson Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

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.1158/1940-6207.CAPR-13-0409 ) Younes M Honma N 2011 Estrogen receptor beta . Archives of Pathology and Laboratory Medicine 135 63 – 66 . ( https://doi.org/10.5858/2010-0448-RAR.1 ) Zhao C Gao H Liu Y Papoutsi Z Jaffrey S Gustafsson JA Dahlman

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Kanchana Suksri Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Namoiy Semprasert Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Mutita Junking Division of Molecular Medicine, Research Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Suchanoot Kutpruek Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Thawornchai Limjindaporn Department of Anatomy, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Pa-thai Yenchitsomanus Division of Molecular Medicine, Research Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Suwattanee Kooptiwut Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Glucocorticoid-induced hyperglycemia . Endocrine Practice 15 469 – 474 . ( https://doi.org/10.4158/EP08331.RAR ) Davani B Portwood N Bryzgalova G Reimer MK Heiden T Ostenson CG Okret S Ahren B Efendic S Khan A 2004 Aged transgenic

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Douglas R Houston Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK

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Jane G Hanna Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK

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J Constance Lathe Program in Neuroscience, University of Glasgow, Glasgow, UK

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Stephen G Hillier Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Richard Lathe Division of Infection Medicine, University of Edinburgh, Edinburgh, UK

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>3.0.CO;2-H ) 9095674 Nakshatri H Chambon P 1994 The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers . Journal of

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Silvia Ottaviani Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK

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Alexander de Giorgio Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK

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Victoria Harding Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK

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Justin Stebbing Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK

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Leandro Castellano Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK

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-receptor-regulated gene activation programs . Nature 500 598 – 602 . ( doi:10.1038/nature12451 ). Zechel C Shen XQ Chambon P Gronemeyer H 1994 The dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR

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