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W M Liu State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing, People’s Republic of China 100080
Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing, People’s Republic of China 100039

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Y J Cao State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing, People’s Republic of China 100080
Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing, People’s Republic of China 100039

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Y J Yang State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing, People’s Republic of China 100080
Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing, People’s Republic of China 100039

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J Li State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing, People’s Republic of China 100080
Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing, People’s Republic of China 100039

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Z Hu State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing, People’s Republic of China 100080
Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing, People’s Republic of China 100039

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E-K Duan State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing, People’s Republic of China 100080
Graduate School of the Chinese Academy of Sciences, 19 Yu-quan Road, Beijing, People’s Republic of China 100039

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pregnancy. Successful invasiveness or migration into the extracellular matrix environment is a fundamental property of embryo implantation. Matrix metalloproteinases (MMPs), one of the well-known families of molecule involved in embryo invasion, were

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01910
Volume/Issue:
Volume 36: Issue 1
Free access
Fabien Duval GIG – EA 7404, Université de Versailles-Saint Quentin en Yvelines – Université Paris Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France

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Esther Dos Santos GIG – EA 7404, Université de Versailles-Saint Quentin en Yvelines – Université Paris Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France
Service de Biologie Médicale, Centre Hospitalier de Poissy-Saint Germain, Poissy, France

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Benoît Maury GIG – EA 7404, Université de Versailles-Saint Quentin en Yvelines – Université Paris Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France

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Valérie Serazin GIG – EA 7404, Université de Versailles-Saint Quentin en Yvelines – Université Paris Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France
Service de Biologie Médicale, Centre Hospitalier de Poissy-Saint Germain, Poissy, France

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Khadija Fathallah Département de Biologie de la Reproduction, Cytogénétique, Gynécologie et Obstétrique, Centre Hospitalier de Poissy-Saint Germain, Poissy, France

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François Vialard GIG – EA 7404, Université de Versailles-Saint Quentin en Yvelines – Université Paris Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France
Département de Biologie de la Reproduction, Cytogénétique, Gynécologie et Obstétrique, Centre Hospitalier de Poissy-Saint Germain, Poissy, France

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Marie-Noëlle Dieudonné GIG – EA 7404, Université de Versailles-Saint Quentin en Yvelines – Université Paris Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France

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Introduction Efficient nutrient exchange between the mother and the fetus is essential for a successful pregnancy and requires adequate placental development. The human placenta is a transient organ composed of embryo-derived cells called

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0013
Volume/Issue:
Volume 61: Issue 3
Free access
Wenlong Zhang College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China

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Zelin Zhang College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China

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Jiang Peng College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China

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Sitian Yang College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China

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Dewen Tong College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China

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pregnancy ( Stocco et al . 2007 ). The process is mainly regulated by hypothalamic GnRH and pituitary LH. Recently, we described the presence of MT1 and MT2 in the CL of pregnant sows and that there exists a stimulatory role for melatonin in the P4

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0155
Volume/Issue:
Volume 68: Issue 2
Restricted access
Cathrin Brisken ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, Lausanne, Switzerland
Breast Cancer Now Research Centre, Institute of Cancer Research, London, UK

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Valentina Scabia ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, Lausanne, Switzerland

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Introduction A woman’s risk to get breast cancer is affected by her reproductive history and hence exposure to reproductive hormones. An early full-term pregnancy has protective effects ( MacMahon et al. , 1970 ), whereas risk increases with

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-20-0091
Volume/Issue:
Volume 65: Issue 1
Free access
Qinyun Ma
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Jianxia Fan Shanghai Key Laboratory for Endocrine Tumors and E-Institute of Shanghai Universities, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, China National Clinical Research for Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Jiqiu Wang
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Shuai Yang Shanghai Key Laboratory for Endocrine Tumors and E-Institute of Shanghai Universities, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, China National Clinical Research for Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Qing Cong Shanghai Key Laboratory for Endocrine Tumors and E-Institute of Shanghai Universities, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, China National Clinical Research for Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Rui Wang
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Qianqian Lv
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Ruixin Liu
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Guang Ning
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studies indicated that moderate inflammation during pregnancy is correlated with IR and GDM ( Wolf et al . 2004 , Kinalski et al . 2005 , de Castro et al . 2011 ). Chorionic gonadotrophin (CG) is produced by the placenta and binds to the luteinising

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0284
Volume/Issue:
Volume 54: Issue 2
Free access
ChengCheng Lin Department of Surgery Laboratory, First Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

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Bei Shao Department of Surgery Laboratory, First Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

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YuLei Zhou Department of Surgery Laboratory, First Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

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XiaoTing Niu Department of Surgery Laboratory, First Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

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YuanShao Lin Department of Surgery Laboratory, First Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

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childhood ( Deutsch et al . 2009 ), it remains to be established whether HFD consumption during pregnancy and the suckling period can influence the cerebrovascular health of adult offspring. Activation of the hypothalamic–pituitary–adrenal (HPA) axis is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0226
Volume/Issue:
Volume 56: Issue 2
Free access
Nora Martínez Laboratory of Reproduction and Metabolism, CEFYBO‐CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina

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Melisa Kurtz Laboratory of Reproduction and Metabolism, CEFYBO‐CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina

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Evangelina Capobianco Laboratory of Reproduction and Metabolism, CEFYBO‐CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina

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Romina Higa Laboratory of Reproduction and Metabolism, CEFYBO‐CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina

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Verónica White Laboratory of Reproduction and Metabolism, CEFYBO‐CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina

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Alicia Jawerbaum Laboratory of Reproduction and Metabolism, CEFYBO‐CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina

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pregnancies ( Jawerbaum & White 2010 ). These models have been valuable to address the causes of these impairments, which are related, at least in part, to the intrauterine metabolic impairments and the consequent generation of an excess of reactive oxygen and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0173
Volume/Issue:
Volume 47: Issue 1
Free access
H O D Critchley MRC Centre for Reproductive Health, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh Bioquarter, Edinburgh, UK

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R R Chodankar MRC Centre for Reproductive Health, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh Bioquarter, Edinburgh, UK

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( Lusher et al . 2011 ). Progesterone plays a vital role in the structure, function and regulation of the female reproductive tract, including pregnancy. Progesterone mediates its function by interacting with the PR, a member of a superfamily of almost 50

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-19-0238
Volume/Issue:
Volume 65: Issue 1
Open access
Xue Wen Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China

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Yao Xiong Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China

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Huimin Liu Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China

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Ting Geng Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China

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Ling Jin Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China

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Ming Zhang Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China

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Ling Ma Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China

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Yuanzhen Zhang Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China
Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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expression was faint throughout the whole early pregnancy period ( Fig. 1B ). In the estrous cycle, the expression of MLL1 was strong in the phase of metestrus in control mice but was weak through the whole cycle in EM mice (Supplementary Fig. 2). The

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0193
Volume/Issue:
Volume 66: Issue 1
Restricted access
A Pestka
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B Toth Department of Obstetrics and Gynaecology–Innenstadt, Department of Obstetrics and Gynaecology, Ludwig‐Maximilians‐University Munich, Maistrasse 11, 80337 Munich, Germany

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C Kuhn
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S Hofmann
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I Wiest
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G Wypior
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K Friese
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U Jeschke
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). During pregnancy, the prostaglandin 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-J 2 ) promotes apoptosis of trophoblasts and weakens their differentiation ( Schaiff et al . 2000 ). Recently, we detected the expression of RXRα in the nuclei of villous

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0002
Volume/Issue:
Volume 47: Issue 2
Free access