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R A Gadkari Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

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S Roy Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

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N Rekha Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

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N Srinivasan Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

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R R Dighe Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

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Introduction Human chorionic gonadotrophin (hCG) is secreted by the trophoblastic cells of the placenta during early pregnancy ( Fox 1970 ). hCG plays an important role in the rescue of the corpus luteum and maintenance of pregnancy

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01683
Volume/Issue:
Volume 34: Issue 3
Free access
Jarrod Bailey School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK

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Alison J Tyson-Capper (née Pollard) School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK

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Kate Gilmore School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK

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Stephen C Robson School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK

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G Nicholas Europe-Finner School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK

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. 2000 , 2002 ). In the latter context, an increased level of cAMP in human myometrial smooth-muscle cells during pregnancy has been reported ( Europe-Finner et al. 1993 , 1994 ), potentiated by altered expression of various components of the cAMP

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01594
Volume/Issue:
Volume 34: Issue 1
Free access
Yachao Zhang Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Ji’nan, Shandong, China

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Jieqiong Yang Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

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Shijian Lv Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

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Dong-Qin Zhao Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Ji’nan, Shandong, China

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Zi-Jiang Chen Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

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Wei-Ping Li Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

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Cong Zhang Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Ji’nan, Shandong, China

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Introduction Preeclampsia (PE) is a pregnancy-specific disorder defined by new onset of hypertension and proteinuria after 20 weeks of gestation. PE is unique to humans, affecting 2–7% of pregnancies ( Hauth et al. 2000 , Sibai et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0180
Volume/Issue:
Volume 60: Issue 2
Free access
Seung-Chul Kim Department of Obstetrics and Gynecology, Biomedical Research Institute, Pusan National University School of Medicine, Pusan, Korea

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Jae-Eon Lee Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan, Korea

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Seong Soo Kang Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea

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Hoe-Saeng Yang Department of Obstetrics and Gynecology, Medical College, Dongguk University, Jung-gu, Korea

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Sun Suk Kim Department of Obstetrics and Gynecology, Biomedical Research Institute, Pusan National University School of Medicine, Pusan, Korea

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Beum-Soo An Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan, Korea

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Introduction The placenta is a transient tissue that performs many functions for the maintenance of pregnancy. In humans, the specific structure of the placenta is apparent as early as 21 weeks of pregnancy ( Benirschke et al . 1998 ). During

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0223
Volume/Issue:
Volume 59: Issue 3
Free access
Oscar J Pozo Integrative Pharmacology and Systems Neuroscience Group, IMIM, Hospital del Mar, Barcelona, Spain

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Josep Marcos Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
Cerba Internacional, Barcelona, Spain

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Olha Khymenets Integrative Pharmacology and Systems Neuroscience Group, IMIM, Hospital del Mar, Barcelona, Spain

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Andy Pranata Research School of Chemistry, Australian National University, Canberra, Australia

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Christopher C Fitzgerald Research School of Chemistry, Australian National University, Canberra, Australia

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Malcolm D McLeod Research School of Chemistry, Australian National University, Canberra, Australia

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Cedric Shackleton Institute of Metabolism and Systems Research (IMSR), University of Birmingham, College of Medical and Dental Sciences, Birmingham, UK
UCSF Benioff Children’s Hospital Oakland Research Institute, Oakland, California, USA

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(PORD) ( Arlt et al . 2004 , Shackleton et al . 2004 a , b , 2007 , Marcos et al . 2009 , Reisch et al . 2013 ). This communication offers our preliminary observations of the disulfated steroids excreted in these disorders at around mid-pregnancy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0286
Volume/Issue:
Volume 61: Issue 2
Free access
Yang Mi Obstetrical Department, Department of Obstetrics and Gynecology, Northwest Women's and Children's Hospital, 1616 Yanxiang Road, Xi'an, Shanxi Province 710061, China

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Na Guo Obstetrical Department, Department of Obstetrics and Gynecology, Northwest Women's and Children's Hospital, 1616 Yanxiang Road, Xi'an, Shanxi Province 710061, China

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Tongqiang He Obstetrical Department, Department of Obstetrics and Gynecology, Northwest Women's and Children's Hospital, 1616 Yanxiang Road, Xi'an, Shanxi Province 710061, China

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Jing Ji Obstetrical Department, Department of Obstetrics and Gynecology, Northwest Women's and Children's Hospital, 1616 Yanxiang Road, Xi'an, Shanxi Province 710061, China

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Zhibin Li Obstetrical Department, Department of Obstetrics and Gynecology, Northwest Women's and Children's Hospital, 1616 Yanxiang Road, Xi'an, Shanxi Province 710061, China

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Pu Huang Obstetrical Department, Department of Obstetrics and Gynecology, Northwest Women's and Children's Hospital, 1616 Yanxiang Road, Xi'an, Shanxi Province 710061, China

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Introduction Gestational diabetes mellitus (GDM) is a disease resulting from insufficient insulin production during pregnancy ( American Diabetes Association 2004 ). GDM patients are commonly diagnosed in the second trimester during pregnancy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0100
Volume/Issue:
Volume 55: Issue 3
Free access
William Davies School of Psychology, Cardiff University, Cardiff, UK
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics and Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK
Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK

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free steroids including DHEA(S). Changes in the steroid sulfate axis throughout mammalian pregnancy and the postpartum period Throughout the childbearing process, women experience considerable hormonal fluctuations, including with regard to the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-17-0219
Volume/Issue:
Volume 61: Issue 2
Free access
Yoshihiro Suzuki Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Keiko Nakahara Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Keisuke Maruyama Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Rieko Okame Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Takuya Ensho Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Yoshiyuki Inoue Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Noboru Murakami Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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proestrus at the age of 10–11 weeks, and the day after mating was counted as day 1 of pregnancy. Rats on day 14 of pregnancy were used in Experiment 3. Lactating rats were mated at 9–10 weeks of age and housed singly with their litters at 13–16 weeks of age

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0015
Volume/Issue:
Volume 52: Issue 2
Open access
Caitlyn Nguyen-Ngo Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia

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Nanthini Jayabalan Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
Exosome Biology Laboratory, Centre for Clinical Diagnostics, The University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, Australia

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Carlos Salomon Exosome Biology Laboratory, Centre for Clinical Diagnostics, The University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, Australia
Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile

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Martha Lappas Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia

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Introduction Gestational diabetes mellitus (GDM) is defined as glucose intolerance of variable severity with first recognition during pregnancy ( HAPO Study Cooperative Research Group et al. 2008 ). GDM is the most common pregnancy

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0274
Volume/Issue:
Volume 63: Issue 3
Free access
Jie Yang Department of Pathophysiology, Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, People's Republic of China

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Jianyu Shang Department of Pathophysiology, Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, People's Republic of China

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Suli Zhang Department of Pathophysiology, Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, People's Republic of China

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Hao Li Department of Pathophysiology, Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, People's Republic of China

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Huirong Liu Department of Pathophysiology, Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, People's Republic of China
Department of Pathophysiology, Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, People's Republic of China

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compensatory and delicate changes of RAAS during normal pregnancy are hard to counterbalance for preeclamptic women, resulting in body capillary constriction, renal damages, disorders of salt and water balance, etc. However, the etiology of this dysfunction

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-12-0216
Volume/Issue:
Volume 50: Issue 2
Free access