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Karine Rizzoti Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK

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border of the neural plate. These involve fibroblast growth factor (FGF) signalling inducing neural fate, bone morphogenetic proteins (BMPs) and wingless-related integration site (WNT) activities inducing future epidermal identity in non-neural ectoderm

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0237
Volume/Issue:
Volume 54: Issue 2
Open access
Tomoko Tanaka Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Shigeki Gondo Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Taijiro Okabe Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Kenji Ohe Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Hisao Shirohzu Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Hidetaka Morinaga Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Masatoshi Nomura Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Kenzaburo Tani Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Hajime Nawata Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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Toshihiko Yanase Department of Medicine and Bioregulatory Science Graduate School of Medical Science, Department of Molecular Genetics Medical Institute of Bioregulationand Graduate School of Medical Science Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

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factors, such as pre-B-cell leukemia homeobox 1 (PBX-1; Schnabel et al . 2003 ), CBP/p300-interacting transactivator with Glu/Asp-rich C-terminal domain 2 (CITED2; Bamforth et al . 2001 ), wingless type MMTV integration site family member 4 (WNT4

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-07-0076
Volume/Issue:
Volume 39: Issue 5
Free access
Michael A Gentile
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Pascale V Nantermet
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Robert L Vogel
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Robert Phillips Merck Research Laboratories, Department of Molecular Profiling, Merck Research Laboratories, Department of Molecular Endocrinology, West Point, Pennsylvania 19486, USA

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Daniel Holder Merck Research Laboratories, Department of Molecular Profiling, Merck Research Laboratories, Department of Molecular Endocrinology, West Point, Pennsylvania 19486, USA

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Paul Hodor Merck Research Laboratories, Department of Molecular Profiling, Merck Research Laboratories, Department of Molecular Endocrinology, West Point, Pennsylvania 19486, USA

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Chun Cheng Merck Research Laboratories, Department of Molecular Profiling, Merck Research Laboratories, Department of Molecular Endocrinology, West Point, Pennsylvania 19486, USA

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Hongyue Dai Merck Research Laboratories, Department of Molecular Profiling, Merck Research Laboratories, Department of Molecular Endocrinology, West Point, Pennsylvania 19486, USA

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Leonard P Freedman
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William J Ray
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myogenic lineage while inhibiting adipogenic differentiation by modulating nuclear translocation of β-catenin ( Bhasin et al . 2006 ). β-Catenin, through its action in cell adhesion and Wnt signal transduction, plays a critical role in embryonic

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0048
Volume/Issue:
Volume 44: Issue 1
Free access
Ana Pestana Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal

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João Vinagre Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal

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Manuel Sobrinho-Simões Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal
Medical Faculty, University of Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar S. João, Porto, Portugal
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal

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Paula Soares Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal
Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal
Medical Faculty, University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal

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Summary of multiple interactions of TERT with major signalling pathways, namely c-MYC, NF-κB and Wnt/B-Catenin pathways. TERT Interaction effects Cell effects References c-MYC Induction of TERT transcriptional activity Induction

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0195
Volume/Issue:
Volume 58: Issue 2
Free access
Caroline H Diep Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Andrea R Daniel Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Laura J Mauro Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Todd P Knutson Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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Carol A Lange Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division
Hematology, Departments of Medicine, Pharmacology, Division of Physiology and Growth, Oncology, and Transplantation Division

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paracrine mechanisms ( Brisken 2013 ); PR-target genes include secreted factors (wnt4) that act on nearby PR-negative cells. In contrast to ER and PR cooperative actions in the breast, progesterone opposes ER actions in the ovary and endometrium, and acts in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0252
Volume/Issue:
Volume 54: Issue 2
Free access
Ying Ying School of Medicine, Department of Geriatric, Shenzhen University Diabetes Center, Shenzhen University, Shenzhen 518060, China

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Huazhang Zhu School of Medicine, Department of Geriatric, Shenzhen University Diabetes Center, Shenzhen University, Shenzhen 518060, China

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Zhen Liang School of Medicine, Department of Geriatric, Shenzhen University Diabetes Center, Shenzhen University, Shenzhen 518060, China
School of Medicine, Department of Geriatric, Shenzhen University Diabetes Center, Shenzhen University, Shenzhen 518060, China

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Xiaosong Ma School of Medicine, Department of Geriatric, Shenzhen University Diabetes Center, Shenzhen University, Shenzhen 518060, China

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Shiwei Li School of Medicine, Department of Geriatric, Shenzhen University Diabetes Center, Shenzhen University, Shenzhen 518060, China

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-induced cardiomyocyte apoptosis remain incompletely clarified. Wnt and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signalling pathways converge through beta-catenin (b-catenin)-mediated regulation of cell survival/apoptosis in different cell types

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0155
Volume/Issue:
Volume 55: Issue 3
Open access
Alexander Kot Center for Musculoskeletal Health, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, USA

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Zhendong A Zhong Center for Musculoskeletal Health, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, USA
Center for Cancer and Cell Biology, Program in Skeletal Disease and Tumor Microenvironment, Van Andel Research Institute, Grand Rapids, Michigan, USA

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Hongliang Zhang Center for Musculoskeletal Health, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, USA
Department of Emergency Medicine, Center for Difficult Diagnoses and Rare Diseases, Second Xiangya Hospital of the Central-South University, Changsha, Hunan, China

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Yu-An Evan Lay Center for Musculoskeletal Health, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, USA

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Nancy E Lane Center for Musculoskeletal Health, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, USA

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Wei Yao Center for Musculoskeletal Health, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, USA

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). Notably, the Tnf gene was 26-fold downregulated and the Tnfrsf1b gene was 2.5-fold downregulated in the PRcKO males. Bone anabolic pathways in male PRcKO Next, we selected those pathways which were related to bone anabolism including Wnt

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0076
Volume/Issue:
Volume 59: Issue 4
Free access
Dorka Nagy Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK
National Heart and Lung Institute, Imperial College London, London, UK

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Hannah Maude Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

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Graeme M Birdsey National Heart and Lung Institute, Imperial College London, London, UK

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Anna M Randi National Heart and Lung Institute, Imperial College London, London, UK

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Inês Cebola Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

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and nutrients are exported into the LSECs and liver parenchyma, while metabolism products and other cell exports enter the blood ( Fig. 1 ). This structure creates a gradient of oxygen, nutrients, and signalling molecules including Wnt morphogens, a

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0026
Volume/Issue:
Volume 71: Issue 2
Open access
Masaki Shiota Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Akira Yokomizo Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Seiji Naito Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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to LEF/TCF-binding  site Yang et al . (2006) LEF1 Transcription factor Hair cell differentiation, follicle morphogenesis, and cellular transformation LNCaP,  AI-LNCaP + Direct Binding to LEF/TCF-binding  site Li et al . (2009) Wnt-1 Cytokine

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0018
Volume/Issue:
Volume 47: Issue 1
Free access
Angela M Davis Animal Sciences, Departments of
Animal Sciences, Departments of

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Jiude Mao Animal Sciences, Departments of

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Bushra Naz Animal Sciences, Departments of

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Jessica A Kohl Animal Sciences, Departments of

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Cheryl S Rosenfeld Animal Sciences, Departments of

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ha1 , Parvb , Rdx , Thbs2 , Tnc , and Tns1 ), in the Wnt/hedgehog/smoothened signaling pathway (dapper homology 1 ( Dact1 ), patched homolog 2 ( Ptch2 ), and secreted frizzled-related protein 1 ( Sfrp1 ), Wnt inhibitory factor 1 ( Wif1 ), SUMO

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0029
Volume/Issue:
Volume 41: Issue 4
Free access