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Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
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Chertow TE Cordle MB Matthews KA Chertow BS 1997 Vitamin A stimulation of insulin secretion: effects on transglutaminase mRNA and activity using rat islets and insulin-secreting cells . Pancreas 15 69 – 77 . doi:10
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Vitamin A concentration in breast adipose tissue of breast cancer patients . Anticancer Research 15 1593 – 1596 .
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. ( doi:10.1038/nsb979 ). Sucov HM Dyson E Gumeringer CL Price J Chien KR Evans RM 1994 RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis . Genes and Development 8 1007 – 1018 . ( doi:10.1101/gad
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Instituto de Investigaciones Biomédicas, Centro Nacional de Biotecnología, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
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-Silva et al . 2011 ). The TRβ promoter is methylated in early stage breast cancer tumors ( Li et al . 2002 ). The same occurs with the retinoic acid receptor β (RARβ). Retinoic acid (RA), an active metabolite of vitamin A, plays a key role in development
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, adjunctive therapies have been investigated with the purpose to restore RAI sensitivity in poorly differentiated TC, termed as redifferentiation. Initially, these were vitamin A derivatives (retinoic acid, bexarotene), PPARγ activators (thiazolidinediones
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.0 Chemical composition b Digestive energy (MJ/kg) 13.39 Crude protein 157.3 Calcium 6.5 Total phosphorus 4.1 Available phosphorus 1.7 Lysine 9.2 Met+Cys 5.4 a Premix provided the following per kg of complete diet for finisher pigs: vitamin A, 2512 IU
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.1006/jmbi.1999.3457 ). Zhou XE Suino-Powell KM Xu Y Chan CW Tanabe O Kruse SW Reynolds R Engel JD Xu HE 2011 The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor . Journal of Biological Chemistry 286 2877
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et al . 2005 ). Although it is a transport protein for vitamin A (retinol), RBP4 has been recognized as an adipokine that affects systemic insulin sensitivity and glucose homeostasis ( Graham et al . 2006 ). Serum RBP4 levels are upregulated in
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preformed vitamin A, exert their function through the binding of nuclear receptors (RAR and RXR) and forming complexes with conserved sequences on gene promoters termed retinoic acid response elements ( Mark et al . 2006 ). 13- Cis retinoic acid (13cRA) is
Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada
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Gerald Bronfman Department of Oncology, Jewish General Hospital, Montreal, Canada
Lady Davis Institute for Medical Research, Montreal, Canada
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Huang and colleagues in China first reported dramatic responses in APL patients to an oral therapy with ATRA, an active form of vitamin A ( Huang et al. 1988 ). Figure 1 Timeline of molecular and therapeutic advances in acute promyelocytic
