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-0153 . The expression of protein level of receptivity markers like Integrin β3, IGFBP1, WNT4, Cyclin E and HBEGF was significantly downregulated ( P < 0.001) in siRNA-injected horn as compared to that in scrambled siRNA (control) group ( Fig. 3C ) as
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During pregnancy, the uterus shows marked morphological and physiological changes under the regulation of ovarian steroid. To elucidate the molecular cues of these changes, we tried to identify the transcripts differentially expressed in the pregnant rat uterus by using the suppression subtractive hybridization method. Seven independent clones were isolated and one of the up-regulated genes was secreted frizzled-related protein 4 (sFRP4). sFRP4 contains a Wnt-binding domain and belongs to the secreted frizzled protein family whose members are assumed to function as modulators of the Wnt signal. The expression level of sFRP4 mRNA reached a peak in the pregnant uterus on day 12, when uterine decidualization was almost complete in the rat. In situ hybridization histochemistry revealed that sFRP4 transcripts were observed in the decidual cells. In addition, proliferating cell nuclear antigen (PCNA)-positive cells were shown to be overlapped in decidua, suggesting that sFRP4 mRNA expression was accompanied by the late phase of decidual cell proliferation. Moreover, sFRP4 and estrogen receptor-alpha transcripts were co-localized. Furthermore, we analyzed the regulation of sFRP4 by estrogen using 17 beta-estradiol-treated ovariectomized rats. sFRP4 mRNA was detected in the uterus at 48 h after estrogen treatment, especially in endometrial stroma where PCNA-positive cells were also observed. The results in this study led us to the notion that sFRP4 mRNA may be up-regulated after estrogen treatment in the late phase of uterine cell proliferation.
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Department of Neonatology, Department of Neonatology, Department of Pediatric Neurology, Central Laboratory, Department of Endocrinology, The Children's Hospital, Zhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, Hangzhou 310003, China
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heart failure have revealed that the NF-κB, transforming growth factor β, Hedgehog, and Wnt pathways mediate the left ventricular (LV) hypertrophy ( de Jesus Perez et al . 2009 , Hou et al . 2009 , Laumanns et al . 2009 ). Other researchers
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mechanisms have been largely unknown. The Wnt-β-catenin signaling pathway is well identified in regulating embryo implantation process ( Sonderegger et al. 2010 ). As reported, the Wnt-β-catenin signaling pathway is critically involved in trophoblast
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, RSPO1 , and WNT4 , and highlight new insights into the delicate balance between the testis- and ovary-determining pathways. Table 1 Genes involved in the male and female sex determination pathway Gene Protein function Gain- and loss
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functionally interacts with Shh in activating capsular Gli1 expression in a β1integrin-dependent fashion ( Guasti et al. 2013 ). Further study of Dlk1 in adrenal self-renewal and tumour development is ongoing. Wnt/β-catenin signalling pathway Another
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as parathyroid hormone-related peptide (PTHrP), Indian hedgehog (IHH), bone morphogenetic proteins (BMPs), wingless/integrated proteins (Wnts), fibroblast growth factors (FGFs), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF
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known that osteoprogenitor maturation is controlled by several extracellular signals including bone morphogenetic proteins (BMPs), hedgehogs, WNTs, and fibroblast growth factors, the actions of which lead to the expression of chondroblast- or osteoblast
Division of Reproductive Sciences, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA
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Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA
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Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
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production. This suggests that local IGF1 is not a direct mediator to estrogen effects in the uterus, but rather systemic IGF1 may be the key factor for growth. Wnt signaling The biological effect of estrogen can also be associated with Wnt signaling
Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Department of Zoology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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Department of Reproductive Endocrinology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
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cytoskeleton protein responsible for cell–cell adhesion, and it negatively regulates the Wnt signaling pathway ( Gates & Peifer 2005 , Sun et al . 2014 ). Exploring the function of the miR-183 family and their potential target genes in endometrial receptivity
