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Maria Sörhede Winzell Division of Medicine, Department of Clinical Sciences, Lund University, BMC, B11, SE-221 84 Lund, Sweden

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Bo Ahrén Division of Medicine, Department of Clinical Sciences, Lund University, BMC, B11, SE-221 84 Lund, Sweden

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the islet β-cell: augmentation of cell proliferation and inhibition of apoptosis . Endocrinology 144 5145 – 5148 . Drucker DJ 2006 The biology of incretin hormones . Cell Metabolism 3 153 – 165 . Drucker DJ Nauck MA 2006 The incretin system

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-07-0121
Volume/Issue:
Volume 40: Issue 2
Free access
Takumi Nakamura Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan

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Kazuki Harada Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Taichi Kamiya Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Mai Takizawa Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Jim Küppers Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Bonn, Germany

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Kazuo Nakajima Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan

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Michael Gütschow Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Bonn, Germany

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Tetsuya Kitaguchi Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan

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Kunihiro Ohta Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Tadafumi Kato Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan

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Takashi Tsuboi Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Introduction Glucagon-like peptide-1 (GLP-1) is a member of the incretin family and is secreted by the gastrointestinal endocrine L cells ( Harada et al. 2017 , 2018 a , b , Drucker 2018 ). GLP-1 regulates the increase in insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0260
Volume/Issue:
Volume 64: Issue 3
Restricted access
Verónica Sancho Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain
Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium

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María V Trigo Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain
Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium

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Nieves González Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain
Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium

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Isabel Valverde Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain
Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium

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Willy J Malaisse Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain
Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium

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María L Villanueva-Peñacarrillo Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain
Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium

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incretin ( Creutzfeldt 2001 ) modulates the glucose transporter levels in 3T3-L1 adipocytes ( Wang et al. 1997 ) and in liver, fat tissue and skeletal muscle of normal and diabetic rats ( Villanueva-Peñacarrillo et al. 2001 b ). In fat tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01747
Volume/Issue:
Volume 35: Issue 1
Free access
Lykke Blaabjerg Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA
Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA

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Gitte L Christensen Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA

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Masahito Matsumoto Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA

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Talitha van der Meulen Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA

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Mark O Huising Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA

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Nils Billestrup Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA

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Wylie W Vale Clayton Foundation Laboratories for Peptide Biology, Cellular and Metabolic Research Section, Salk Institute, 10100 North Torrey Pines Road, La Jolla, California 92037, USA

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class B G-protein-coupled receptors (GPCRs), as do receptors for incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP1) ( Brubaker & Drucker 2002 ). This subclass of receptors couples with Gαs and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0056
Volume/Issue:
Volume 53: Issue 3
Free access
Srividya Vasu SAAD Centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK

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R Charlotte Moffett SAAD Centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK

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Neville H McClenaghan SAAD Centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK

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Peter R Flatt SAAD Centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK

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al . 2011 , Kielgast et al . 2011 , Unger 2013 ). Recent investigations together with our unpublished observations have revealed that disturbances in the intestinal L-cell population may contribute to the loss-of-functional incretin response in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0214
Volume/Issue:
Volume 54: Issue 1
Free access
Özlem Erdogdu
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Linnéa Eriksson
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Hua Xu Department of Clinical Science and Education, Department of Pathophysiology, Karolinska Institutet, Södersjukhuset AB, SE-118 83 Stockholm, Sweden

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Åke Sjöholm
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Qimin Zhang
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Thomas Nyström
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). Exendin-4, a stable incretin mimetic and GLP1 receptor agonist, has been shown to promote glucose-dependent insulin secretion in vitro ( Parkes et al . 2001 ). Besides its insulinotropic action, exendin-4 may also exert direct beneficial effects on

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0166
Volume/Issue:
Volume 50: Issue 2
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Franziska Boess
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Cristina Bertinetti-Lapatki
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Sannah Zoffmann
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Catherine George F. Hoffmann-La Roche Ltd., Ipsen Innovation, Human Tissue Bank operated under the authority of HTCR Foundation, Non Clinical Safety, Grenzacherstrasse 124, 4070 Basel, Switzerland

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Thomas Pfister
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Adrian Roth
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Serene M L Lee F. Hoffmann-La Roche Ltd., Ipsen Innovation, Human Tissue Bank operated under the authority of HTCR Foundation, Non Clinical Safety, Grenzacherstrasse 124, 4070 Basel, Switzerland

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Wolfgang E Thasler F. Hoffmann-La Roche Ltd., Ipsen Innovation, Human Tissue Bank operated under the authority of HTCR Foundation, Non Clinical Safety, Grenzacherstrasse 124, 4070 Basel, Switzerland

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Thomas Singer
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Laura Suter
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Introduction Glucagon-like peptide 1 (GLP1) is an incretin hormone that promotes glucose-dependent stimulation of insulin and suppression of glucagon secretion, delays gastric emptying, and reduces energy intake. GLP1 also increases β-cell mass via

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0186
Volume/Issue:
Volume 50: Issue 3
Free access
Patricia K Russell Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Michele V Clarke Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Jarrod P Skinner Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Tammy P S Pang Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Jeffrey D Zajac Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Rachel A Davey Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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, which encodes dipeptidyl peptidase 4 (DPP4). DPP4 plays a major role in glucose metabolism by degrading incretins, the gastrointestinal hormones that increase insulin secretion from β-cells after eating, before the rise in blood glucose ( Drucker & Nauck

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0014
Volume/Issue:
Volume 49: Issue 1
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Sushi Jiang Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Hening Zhai Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China
Endoscopy Center, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China

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Danjie Li Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Jiana Huang Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Heng Zhang Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Ziru Li Shenzhen University Diabetes Center, Shenzhen University Health Science Center, Shenzhen, Guangdong, China

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Weizhen Zhang Shenzhen University Diabetes Center, Shenzhen University Health Science Center, Shenzhen, Guangdong, China
Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA

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Geyang Xu Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes . Diabetes Care 29 2632 – 2637 . ( doi:10.2337/dbib6-0703 ) Baggio LL Drucker DJ 2007 Biology of incretins: GLP-1 and GIP . Gastroenterology 132 2131 – 2157

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0099
Volume/Issue:
Volume 57: Issue 3
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Aqfan Jamaluddin Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Caroline M Gorvin Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory peptide, GIP) are gut-derived hormones known as incretins, as they promote the secretion of insulin. GLP-1 is processed from the pro

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0014
Volume/Issue:
Volume 70: Issue 4
Open access