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Riccarda Granata
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Marco Volante Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Fabio Settanni
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Carlotta Gauna Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Corrado Ghé Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Marta Annunziata
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Barbara Deidda Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Iacopo Gesmundo
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Thierry Abribat Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Aart-Jan van der Lely Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Giampiero Muccioli Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Ezio Ghigo
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Mauro Papotti Laboratory of Molecular and Cellular Endocrinology, Department of Clinical and Biological Sciences, Department of Anatomy, Alizé Pharma, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy

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Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2 . Molecular and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0141
Volume/Issue:
Volume 45: Issue 1
Free access
Aqfan Jamaluddin Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Caroline M Gorvin Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory peptide, GIP) are gut-derived hormones known as incretins, as they promote the secretion of insulin. GLP-1 is processed from the pro

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0014
Volume/Issue:
Volume 70: Issue 4
Open access
Özlem Erdogdu
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Linnéa Eriksson
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Hua Xu Department of Clinical Science and Education, Department of Pathophysiology, Karolinska Institutet, Södersjukhuset AB, SE-118 83 Stockholm, Sweden

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Åke Sjöholm
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Qimin Zhang
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Thomas Nyström
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( Tripathy et al . 2003 ). Glucagon-like peptide-1 (GLP1) is a brain gut insulinotropic hormone that plays an important role in the regulation of glucose homeostasis and thus has been applied in clinical treatment of diabetes ( Drucker & Nauck 2006

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0166
Volume/Issue:
Volume 50: Issue 2
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Sheng Wu
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Graeme J Roch
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Laura A Cervini Department of Biology, Peptide Biology Laboratory, University of Victoria, Victoria BC, Canada V8W 3N5

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Jean E Rivier Department of Biology, Peptide Biology Laboratory, University of Victoria, Victoria BC, Canada V8W 3N5

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Nancy M Sherwood
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 Glucose-dependent insulinotropic polypeptide GIP ++ − ++ GIP Receptor  Pituitary adenylate cyclase-activating polypeptide PAC1R ++ + ++ ADCYAP1R1  GH-releasing hormone-like peptide GHRH-LPR a (PRPR a ) ++ + −  VIP–PACAP receptor 1 VPAC1R ++ + ++ VIPR1

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0083
Volume/Issue:
Volume 41: Issue 5
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Ilitch Aquino Marcondes-de-Castro Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

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Thamiris Ferreira Oliveira Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

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Renata Spezani Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

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Thatiany Souza Marinho Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

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Luiz Eduardo Macedo Cardoso Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

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Marcia Barbosa Aguila Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

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Carlos Alberto Mandarim-de-Lacerda Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

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. ( https://doi.org/10.1073/pnas.2022120118 ) De Block CEM Dirinck E Verhaegen A Van Gaal LF 2022 Efficacy and safety of high-dose glucagon-like peptide-1, glucagon-like peptide-1/glucose-dependent insulinotropic peptide, and glucagon-like peptide

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0168
Volume/Issue:
Volume 70: Issue 3
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Guoqing Lei Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Linxi Chen Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Miao Peng Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Bolin Zeng Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Qiaoxi Yang Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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Hening Zhai Endoscopy Center, The First Affiliated Hospital of Jinan University

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Geyang Xu Department of Physiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

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(7-36) amide form, with a lesser amount of the bioactive GLP-1(7-37) form also detectable ( Kreymann et al. 1987 ). The biological activities of GLP-1 include stimulation of glucose-dependent insulin secretion and insulin biosynthesis, inhibition of glucagon

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0124
Volume/Issue:
Volume 63: Issue 3
Free access
Daniela Nasteska Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Edgbaston, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
COMPARE University of Birmingham and University of Nottingham Midlands, Birmingham, UK

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David J Hodson Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Edgbaston, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
COMPARE University of Birmingham and University of Nottingham Midlands, Birmingham, UK

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/ion channels. Perhaps the best characterised signals are derived from the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) released from the enteroendocrine L-cells and K-cells, respectively, following food

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0011
Volume/Issue:
Volume 61: Issue 1
Open access
Janice K V Tam School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong

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Leo T O Lee School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong

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Jun Jin School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong

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Billy K C Chow School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong

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histidine isoleucine (PHI)/peptide histidine methionine (PHM), growth hormone-releasing hormone (GHRH), secretin (SCT), glucagon (GCG), glucagon-like peptide 1 (GLP1), glucagon-like peptide 2 (GLP2), and glucose-dependent insulinotropic peptide (or gastric

Article Type:
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https://doi.org/10.1530/JME-13-0259
Volume/Issue:
Volume 52: Issue 3
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James E P Brown
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David J Onyango School of Life and Health Sciences, Endocrinology and Metabolism Research Group, Diabetes and Metabolic Disorders Research Group, Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, UK

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Manjunath Ramanjaneya School of Life and Health Sciences, Endocrinology and Metabolism Research Group, Diabetes and Metabolic Disorders Research Group, Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, UK

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Alex C Conner School of Life and Health Sciences, Endocrinology and Metabolism Research Group, Diabetes and Metabolic Disorders Research Group, Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, UK

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Snehal T Patel School of Life and Health Sciences, Endocrinology and Metabolism Research Group, Diabetes and Metabolic Disorders Research Group, Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, UK

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Simon J Dunmore School of Life and Health Sciences, Endocrinology and Metabolism Research Group, Diabetes and Metabolic Disorders Research Group, Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, UK

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Harpal S Randeva School of Life and Health Sciences, Endocrinology and Metabolism Research Group, Diabetes and Metabolic Disorders Research Group, Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, UK

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.775 Glucagon 1.782 0.652 Glucagon receptor 2.297 0.873 Glucose transporter type 4 2.701 0.624 Glucagon-like peptide 1 receptor 1.072 0.284 Glycerol-3-phosphate dehydrogenase 1 (soluble) 2.962 0.172 Glycogen synthase kinase 3β −1.447 0.266 Heme oxygenase

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0071
Volume/Issue:
Volume 44: Issue 3
Free access
Takumi Nakamura Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan

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Kazuki Harada Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Taichi Kamiya Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Mai Takizawa Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Jim Küppers Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Bonn, Germany

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Kazuo Nakajima Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan

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Michael Gütschow Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Bonn, Germany

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Tetsuya Kitaguchi Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan

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Kunihiro Ohta Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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Tadafumi Kato Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan

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Takashi Tsuboi Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

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J Rasmussen C Coy DH Holst JJ 2008 Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas . Diabetologia 2263 – 2270

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0260
Volume/Issue:
Volume 64: Issue 3
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