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Irene I Lee Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Nane C Kuznik Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Eggenstein-Leopoldshafen, Germany

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Jaice T Rottenberg Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Myles Brown Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Andrew C B Cato Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Eggenstein-Leopoldshafen, Germany

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proteins were overexpressed. Although this type of assay has been used to demonstrate the action of several transcription factors in gene regulatory networks, the results from such assays with cochaperones or chaperones should be viewed critically

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-19-0034
Volume/Issue:
Volume 62: Issue 4
Free access
François Chauvigné
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Cinta Zapater
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Diego Crespo Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-Institut de Ciències del Mar, Departament de Fisiologia i Immunologia, Consejo Superior de Investigaciones Científicas (CSIC), Passeig marítim 37-49, 08003 Barcelona, Spain

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Josep V Planas Institut de Recerca i Tecnologia Agroalimentàries (IRTA)-Institut de Ciències del Mar, Departament de Fisiologia i Immunologia, Consejo Superior de Investigaciones Científicas (CSIC), Passeig marítim 37-49, 08003 Barcelona, Spain

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Joan Cerdà
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production of testosterone and 11-KT with respect to that induced by Fsh. Senegalese sole spermatids also express cyp11a1 , cbr1 , and cyp19a1 , but the physiological significance of this observation remains unclear. In mammals, high transcriptional

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0087
Volume/Issue:
Volume 53: Issue 2
Free access
Gioia Altobelli Department of Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

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syntax of a concerted transcriptional activation/repression of many genes, referred to as regulatory networks. The major molecular events that underlie gene transcription primarily include the recognition of specific DNA elements known as transcription

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0060
Volume/Issue:
Volume 49: Issue 2
Free access
Yunguang Tong Department of Medicine, David Geffen School of Medicine at UCLA, Cedars-Sinai Research Institute, Davis Building, Room 3025, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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Tamar Eigler Department of Medicine, David Geffen School of Medicine at UCLA, Cedars-Sinai Research Institute, Davis Building, Room 3025, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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transactivation. In this review, we describe PTTG1 transactivation functions, its role in neoplasis, protein structure, interaction proteins, and transcriptional targets. PTTG1 transcription function and cancer PTTG1 is considered as an oncogene because of its

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0176
Volume/Issue:
Volume 43: Issue 5
Free access
Jaya Nautiyal Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, UK

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Introduction We have come a long way in the understanding of transcriptional coregulators from when they were first identified as transcription factor-binding proteins ( Glass et al . 1990 , Bastian & Nordeen 1991 , Chatterjee et al . 1991

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0156
Volume/Issue:
Volume 58: Issue 3
Free access
Kun Chen Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Ji-Dan Zhou Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Feng Zhang Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Fang Zhang Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Rui-Rui Zhang Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Meng-Si Zhan Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Xiao-Yin Tang Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Bing Deng Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Ming-Gang Lei Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Yuan-Zhu Xiong Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, Wuhan Institute of Animal Science and Veterinary Medicine, and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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of GPR120 . To better understand the transcriptional regulation of GPR120 , we examined the mutations and cis regulation elements of the porcine GPR120 gene by analyzing its 5′ upstream sequence. Our results demonstrate that transcription factor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0200
Volume/Issue:
Volume 56: Issue 2
Free access
L L Burger Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, VA 22908, USA

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D J Haisenleder Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, VA 22908, USA

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A C Dalkin Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, VA 22908, USA

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J C Marshall Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, VA 22908, USA

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regulate either positively or negatively LH and FSH synthesis and secretion. The aims of this review are to present the transcriptional regulation of the gonadotropin subunit genes in a physiologic setting and examine the mechanisms that drive those changes

Article Type:
Review Article
DOI:
https://doi.org/10.1677/jme.1.01600
Volume/Issue:
Volume 33: Issue 3
Free access
Ann Lo
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Weiming Zheng
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Yimei Gong Division of Reproductive Endocrinology, Department of Internal Medicine, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA

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John R Crochet Division of Reproductive Endocrinology, Department of Internal Medicine, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA

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Lisa M Halvorson
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identified transcription factors that regulate expression of the LH β-subunit gene ( LHβ ), including steroidogenic factor-1 (SF-1; NR5A1), liver receptor homologue-1 (LRH-1; NR5A2), pituitary homeobox-1 (Pitx1), early growth response-1, and selective

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0137
Volume/Issue:
Volume 47: Issue 1
Free access
Maria Nygård Department of Biosciences at Novum, Karolinska Institutet, 141 57 Huddinge, Sweden
UMR 5166 CNRS/MNHN, 75231 Paris Cedex 05, France

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Nathalie Becker Department of Biosciences at Novum, Karolinska Institutet, 141 57 Huddinge, Sweden
UMR 5166 CNRS/MNHN, 75231 Paris Cedex 05, France

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Barbara Demeneix Department of Biosciences at Novum, Karolinska Institutet, 141 57 Huddinge, Sweden
UMR 5166 CNRS/MNHN, 75231 Paris Cedex 05, France

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Katarina Pettersson Department of Biosciences at Novum, Karolinska Institutet, 141 57 Huddinge, Sweden
UMR 5166 CNRS/MNHN, 75231 Paris Cedex 05, France

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Maria Bondesson Department of Biosciences at Novum, Karolinska Institutet, 141 57 Huddinge, Sweden
UMR 5166 CNRS/MNHN, 75231 Paris Cedex 05, France

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receptors (TRs) are members of the large nuclear receptor family of transcription factors. As with other members of this superfamily, TR contains an N-terminal domain (A/B), an activation function (AF)-1 domain, a DNA-binding domain (DBD) and a ligand

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01874
Volume/Issue:
Volume 36: Issue 3
Free access
Bassam El-Asmar Reproduction, Department of Obstetrics and Gynecology, Perinatal and Child Health, CHUQ Research Centre, CHUL Room T1-49, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2

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Xavier C Giner Reproduction, Department of Obstetrics and Gynecology, Perinatal and Child Health, CHUQ Research Centre, CHUL Room T1-49, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2

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Jacques J Tremblay Reproduction, Department of Obstetrics and Gynecology, Perinatal and Child Health, CHUQ Research Centre, CHUL Room T1-49, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
Reproduction, Department of Obstetrics and Gynecology, Perinatal and Child Health, CHUQ Research Centre, CHUL Room T1-49, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2

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transcription factors have been implicated in this process. These include steroidogenic factor 1 (SF1, NR5A1), GATA4, CCAAT/enhancer binding protein β (C/EBPβ), sterol regulatory element binding protein (SREBF1), stimulatory protein 1 (SP1), cAMP response

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0016
Volume/Issue:
Volume 42: Issue 2
Free access