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Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
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Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
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. 2012 , Ma et al . 2012 , Wei et al . 2012 , Xu et al . 2012 a , b , Chiyomaru et al . 2013 , Wu et al . 2013 ). Moreover, these six miRNAs have been reported to regulate the WNT signaling pathway ( Chiyomaru et al . 2013 , Liu et al . 2013
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France
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-genomic mechanisms that link androgens signalling to the proliferative and cell survival transduction pathways ( Peterziel et al. 1999 , Migliaccio et al. 2000 , Baron et al. 2004 ). During early foetal life, AR is present only in mesenchymal cells of
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strengthens our understanding of fish ion-osmoregulation. Among different ion-regulatory hormones, the glycoprotein STC1 plays an important role in plasma Ca 2+ homeostasis in fish, but the underlying mechanisms of its post-receptor signaling pathways and
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resorption and osteoblastic bone formation for bone homeostasis ( Delgado-Calle & Bellido 2022 ). These paracrine effects of osteocytes on osteoclasts and osteoblasts are related to their ability to synthesize a variety of different signalling molecules, such
Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Shandong Center of Crop Germplasm Resources, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
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National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
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Department of Urology of Langone Medical Center, New York University, New York, New York, USA
Perlmutter Cancer Institute of Langone Medical Center, New York University, New York, New York, USA
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Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA
Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Icahn Mount Sinai School of Medicine, New York, New York, USA
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, aberrant lipid metabolism and IR ( Kwanten et al. 2014 ), with the involvement of mTOR signaling ( Codogno & Meijer 2010 ). ER is a principal organelle responsible for energy management ( Hotamisligil 2010 ) and the correct folding and maturation of
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Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands
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) expression, and impaired LEPRb signaling (see review Morris & Rui (2009) ). When leptin binds to the LEPRb, one of the pathways activated is the JAK2–STAT3 cascade ( Bjorbaek et al . 1999 ). Phosphorylated STAT3 enters the nucleus and serves as a
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et al. 2018 , 2020 ). Thus, as type 1 diabetes progresses, pancreatic β-cells are exposed to a variety of IFNs and, to marshal an effective response, the cells must interpret and integrate these input signals effectively. The signal transduction
Reproductive Science Research Program, Morehouse School of Medicine, Atlanta, Georgia, USA
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Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia, USA
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/2 signaling pathway ( Rajalingam et al. 2005 , Han et al. 2008 ). Previous studies have shown that PHB is widely expressed in rat ovary and its expression is regulated by age and follicular stage ( Thompson et al. 1999 , 2004 ). Moreover, recent
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, ribosomal protein S6 kinase (S6K) antibody, ribosomal protein S6 (S6) antibody, phospho-S6K antibody and phospho-S6 antibody were purchased from Cell Signaling Technology. Dulbecco’s modified Eagle’s medium (DMEM) was obtained from Gibco Life Technologies
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, the full extent of the regulatory functions of some of these receptors is still unclear. Systematic directed mutagenesis has provided valuable knowledge regarding the molecular mechanisms underlying the signal transduction of the MCRs. It is well