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Changgui Shi Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Ping Huang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Hui Kang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Bo Hu Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Jin Qi Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Min Jiang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Hanbing Zhou Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Lei Guo Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Lianfu Deng Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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. 2012 , Ma et al . 2012 , Wei et al . 2012 , Xu et al . 2012 a , b , Chiyomaru et al . 2013 , Wu et al . 2013 ). Moreover, these six miRNAs have been reported to regulate the WNT signaling pathway ( Chiyomaru et al . 2013 , Liu et al . 2013

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Laurent Léotoing Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Michèle Manin Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Didier Monté Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Silvère Baron Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Yves Communal Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Corinne Lours Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Georges Veyssière Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Laurent Morel Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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Claude Beaudoin Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Université Blaise Pascal, Campus Universitaire des Cézeaux, 24 Avenue des Landais, 63177 Aubière Cedex, France
UMR 8161 Institut de Biologie de Lille/CNRS/Université de Lille 1/Université Lille2/Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
Laboratoire d’Immunologie, Centre Jean Perrin, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France

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-genomic mechanisms that link androgens signalling to the proliferative and cell survival transduction pathways ( Peterziel et al. 1999 , Migliaccio et al. 2000 , Baron et al. 2004 ). During early foetal life, AR is present only in mesenchymal cells of

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J Gu Department of Biology, Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China

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A Y S Law Department of Biology, Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China

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B H Y Yeung Department of Biology, Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China

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Chris K C Wong Department of Biology, Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China

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strengthens our understanding of fish ion-osmoregulation. Among different ion-regulatory hormones, the glycoprotein STC1 plays an important role in plasma Ca 2+ homeostasis in fish, but the underlying mechanisms of its post-receptor signaling pathways and

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Xiangnan Wu Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China

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Yiqiao Wang Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China

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Hang Wang State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China

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Meirui Ma Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China

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Zhichao Hao Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China

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Yuanyuan Ma Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China

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resorption and osteoblastic bone formation for bone homeostasis ( Delgado-Calle & Bellido 2022 ). These paracrine effects of osteocytes on osteoclasts and osteoblasts are related to their ability to synthesize a variety of different signalling molecules, such

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Jie Sun College of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China
Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Yan Liu College of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China
Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Jinhui Yu College of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China
Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Shandong Center of Crop Germplasm Resources, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China

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Jin Wu Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Wenting Gao Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Liyuan Ran Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Rujiao Jiang Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Meihua Guo Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Dongyu Han Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Bo Liu Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Ning Wang Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Youwei Li Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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He Huang Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China

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Li Zeng Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China

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Ying Gao Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, China

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Xin Li Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA
Department of Urology of Langone Medical Center, New York University, New York, New York, USA
Perlmutter Cancer Institute of Langone Medical Center, New York University, New York, New York, USA

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Yingjie Wu College of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China
Institute for Genome Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, Liaoning, China
National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China
Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, Liaoning, China
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA
Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Icahn Mount Sinai School of Medicine, New York, New York, USA

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, aberrant lipid metabolism and IR ( Kwanten et al. 2014 ), with the involvement of mTOR signaling ( Codogno & Meijer 2010 ). ER is a principal organelle responsible for energy management ( Hotamisligil 2010 ) and the correct folding and maturation of

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M W A de Backer Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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M A D Brans Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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A J van Rozen Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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E M van der Zwaal Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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M C M Luijendijk Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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K G Garner Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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M de Krom Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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O van Beekum Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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S E la Fleur Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands
Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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R A H Adan Department of Neuroscience and Pharmacology, Department of Endocrinology and Metabolism, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Universiteitsweg 100, Stratenum 5.203, 3584 CG Utrecht, The Netherlands

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) expression, and impaired LEPRb signaling (see review Morris & Rui (2009) ). When leptin binds to the LEPRb, one of the pathways activated is the JAK2–STAT3 cascade ( Bjorbaek et al . 1999 ). Phosphorylated STAT3 enters the nucleus and serves as a

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Shalinee Dhayal Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Kaiyven Afi Leslie Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Mohammad Baity Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Pouria Akhbari Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Sarah J Richardson Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Mark A Russell Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Noel G Morgan Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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et al. 2018 , 2020 ). Thus, as type 1 diabetes progresses, pancreatic β-cells are exposed to a variety of IFNs and, to marshal an effective response, the cells must interpret and integrate these input signals effectively. The signal transduction

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Indrajit Chowdhury Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia, USA
Reproductive Science Research Program, Morehouse School of Medicine, Atlanta, Georgia, USA

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Kelwyn Thomas Department of Neurobiology, Morehouse School of Medicine, Atlanta, Georgia, USA

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Anthony Zeleznik Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Winston E Thompson Reproductive Science Research Program, Morehouse School of Medicine, Atlanta, Georgia, USA
Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia, USA

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/2 signaling pathway ( Rajalingam et al. 2005 , Han et al. 2008 ). Previous studies have shown that PHB is widely expressed in rat ovary and its expression is regulated by age and follicular stage ( Thompson et al. 1999 , 2004 ). Moreover, recent

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Qi Zhang Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Qin Zhu Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Ruyuan Deng Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Disease, Zhongshan Hospital, Fudan University, Shanghai, China

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Feiye Zhou Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Linlin Zhang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Shushu Wang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Kecheng Zhu Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Xiao Wang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Libin Zhou Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Qing Su Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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, ribosomal protein S6 kinase (S6K) antibody, ribosomal protein S6 (S6) antibody, phospho-S6K antibody and phospho-S6 antibody were purchased from Cell Signaling Technology. Dulbecco’s modified Eagle’s medium (DMEM) was obtained from Gibco Life Technologies

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Davids Fridmanis
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Ramona Petrovska
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Dace Pjanova
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Helgi B Schiöth Latvian Biomedical Research and Study Centre, Department of Neuroscience, Ratsupites 1, LV-1067 Riga, Latvia

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Janis Klovins
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, the full extent of the regulatory functions of some of these receptors is still unclear. Systematic directed mutagenesis has provided valuable knowledge regarding the molecular mechanisms underlying the signal transduction of the MCRs. It is well

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