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Diego Russo
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Giuseppe Damante Dipartimento di Scienze Farmacobiologiche, Dipartimento di Scienze e Tecnologie Biomediche, Dipartimento di Medicina Interna e Specialità Mediche, Dipartimento di Scienze Cliniche, Università di Catanzaro, 88100 Catanzaro, Italy

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Efisio Puxeddu Dipartimento di Scienze Farmacobiologiche, Dipartimento di Scienze e Tecnologie Biomediche, Dipartimento di Medicina Interna e Specialità Mediche, Dipartimento di Scienze Cliniche, Università di Catanzaro, 88100 Catanzaro, Italy

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Cosimo Durante Dipartimento di Scienze Farmacobiologiche, Dipartimento di Scienze e Tecnologie Biomediche, Dipartimento di Medicina Interna e Specialità Mediche, Dipartimento di Scienze Cliniche, Università di Catanzaro, 88100 Catanzaro, Italy

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Sebastiano Filetti Dipartimento di Scienze Farmacobiologiche, Dipartimento di Scienze e Tecnologie Biomediche, Dipartimento di Medicina Interna e Specialità Mediche, Dipartimento di Scienze Cliniche, Università di Catanzaro, 88100 Catanzaro, Italy

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undergoing clinical testing for treatment of aggressive thyroid carcinomas ( Schlumberger & Sherman 2009 ). The differentiation and proliferation properties of thyroid cancer cells are also strongly influenced by epigenetic alterations ( Kondo et al . 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0150
Volume/Issue:
Volume 46: Issue 3
Free access
Soojin Kim Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Daksh Thaper Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Samir Bidnur Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Paul Toren Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Shusuke Akamatsu Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Jennifer L Bishop Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Colin Colins Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Sepideh Vahid Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Amina Zoubeidi Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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-like phenotype, a potential theory which is tested by mechanistically studying the interplay between AR- and NE-driving forces such as neural differentiation regulator BRN2 ( Bishop et al. 2017 ) or growth-promoting paternally expressed gene 10 (PEG10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0226
Volume/Issue:
Volume 63: Issue 1
Free access
Annu Makker Post‐Graduate Department of Pathology, Department of Biochemistry, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

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Madhu Mati Goel Post‐Graduate Department of Pathology, Department of Biochemistry, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

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Abbas Ali Mahdi Post‐Graduate Department of Pathology, Department of Biochemistry, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

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inhibin. While, FSH is mainly involved in follicular growth, cellular proliferation, and estrogen production (aromatase activity), LH induces androgen biosynthesis, final maturation of the oocytes, ovulation, and terminal differentiation of ovulated

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0220
Volume/Issue:
Volume 53: Issue 3
Free access
Yan Meng School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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Maria Toledo-Rodriguez School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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Olena Fedorenko School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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Paul A Smith School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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, differentiation, and expansion of adipocytes – processes that underlie the hypertrophy and hyperplasia of adipose tissue associated with obesity ( Oguri et al. 2010 , Sun et al. 2012 , Zhang et al. 2018 ). Interestingly, these processes are differentially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0108
Volume/Issue:
Volume 72: Issue 4
Open access
I J Bujalska
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M Quinkler
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J W Tomlinson
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C T Montague
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D M Smith
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P M Stewart
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observations in patients with Cushing’s syndrome who develop reversibly central obesity highlight the importance of glucocorticoids in this regard ( Rebuffe-Scrive 1988 ). Glucocorticoids (GCs) induce adipocyte differentiation ( Hauner et al. 1987

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02048
Volume/Issue:
Volume 37: Issue 2
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Raghunath Chatterjee
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Paramita Bhattacharya
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Oksana Gavrilova Laboratory of Metabolism, Mouse Metabolism Laboratory, Physics Department, SAIC Frederick, Veterinary Resources Program, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA

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Kimberly Glass Laboratory of Metabolism, Mouse Metabolism Laboratory, Physics Department, SAIC Frederick, Veterinary Resources Program, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA

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Jaideep Moitra
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Max Myakishev
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Stephanie Pack Laboratory of Metabolism, Mouse Metabolism Laboratory, Physics Department, SAIC Frederick, Veterinary Resources Program, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA

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William Jou Laboratory of Metabolism, Mouse Metabolism Laboratory, Physics Department, SAIC Frederick, Veterinary Resources Program, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA

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Lionel Feigenbaum Laboratory of Metabolism, Mouse Metabolism Laboratory, Physics Department, SAIC Frederick, Veterinary Resources Program, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA

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Michael Eckhaus Laboratory of Metabolism, Mouse Metabolism Laboratory, Physics Department, SAIC Frederick, Veterinary Resources Program, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA

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Charles Vinson
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& Flier 2004 , Steppan & Lazar 2004 , Kadowaki & Yamauchi 2005 ). Transgenic (TG) mice with fat ablation have been produced by inhibition of adipocyte differentiation and development ( Moitra et al . 1998 , Shimomura et al . 1998 , Peterfy et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0172
Volume/Issue:
Volume 46: Issue 3
Free access
Dima W Alhamad Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Husam Bensreti Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Jennifer Dorn Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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William D Hill Department of Pathology, Medical University of South Carolina, Charleston, South Carolina, USA
Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA

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Mark W Hamrick Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Meghan E McGee-Lawrence Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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differentiate into bone-forming osteoblasts ( Stein & Lian 1993 ). MSC undergoes an initial proliferation phase where genes involved in cell cycle and cell growth (e.g. c-Myc and c-Jun ) are highly expressed ( Stein & Lian 1993 ). This phase is accompanied by

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0076
Volume/Issue:
Volume 69: Issue 3
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Luiz Henrique de Castro Assis Reproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Institute of Biodynamics and Biocomplexity, Utrecht University, Utrecht, The Netherlands

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Rafael Henrique de Nóbrega Reproductive and Molecular Biology Group, Department of Morphology, Institute of Bioscience of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil

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Nuria Esther Gómez-González Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, IMIB-Arrixaca, Murcia, Spain

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Jan Bogerd Reproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Institute of Biodynamics and Biocomplexity, Utrecht University, Utrecht, The Netherlands

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Rüdiger Winfried Schulz Reproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Institute of Biodynamics and Biocomplexity, Utrecht University, Utrecht, The Netherlands

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Introduction Spermatogenesis is a complex cellular development, in which spermatogonial stem cells (SSCs) give rise via mitosis to spermatogonia that enter meiosis and spermiogenesis to produce a large number of highly differentiated haploid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0177
Volume/Issue:
Volume 60: Issue 4
Free access
JaeSang Ko Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea

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Ji-Young Kim Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea

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Min Kyoung Chae Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea

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Eun Jig Lee Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

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Jin Sook Yoon Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea

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filtered cigarettes (Marlboro 20 class A cigarettes (8.0 mg tar; 0.7 mg nicotine); Philip Morris Korea, Inc., Seoul, Korea), as described previously ( Yoon et al. 2013 ). Cell culture and differentiation protocols Orbital adipose

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0057
Volume/Issue:
Volume 66: Issue 4
Restricted access
Gábor Bánhegyi Dipartimento di Fisiopatologia, Department of Medical Chemistry, Medicina Sperimentale e Sanità Pubblica, Università di Siena, Via Aldo Moro, 53100 Siena, Italy
Dipartimento di Fisiopatologia, Department of Medical Chemistry, Medicina Sperimentale e Sanità Pubblica, Università di Siena, Via Aldo Moro, 53100 Siena, Italy

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Miklós Csala Dipartimento di Fisiopatologia, Department of Medical Chemistry, Medicina Sperimentale e Sanità Pubblica, Università di Siena, Via Aldo Moro, 53100 Siena, Italy

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Angelo Benedetti Dipartimento di Fisiopatologia, Department of Medical Chemistry, Medicina Sperimentale e Sanità Pubblica, Università di Siena, Via Aldo Moro, 53100 Siena, Italy

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, differentiation, or death, those induced (or repressed) in response to infection, tissue damage, and inflammation, pathways that maintain metabolic homeostasis and those that regulate mood and memory ( Stahn et al . 2007 ). The relative expression levels of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0156
Volume/Issue:
Volume 42: Issue 4
Free access