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Khairul I Ansari Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA

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Imran Hussain Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA

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Sahba Kasiri Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA

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Subhrangsu S Mandal Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA

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cervical cancer cells demonstrated that HOXC10 expression is elevated in invasive cells and linked with the invasiveness of human papillomavirus-immortalized keratinocytes and cervical cancer cells ( Lopez et al . 2006 , Zhai et al . 2007 ). Knockdown

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0078
Volume/Issue:
Volume 48: Issue 1
Free access
F Gadal Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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A Starzec Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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C Bozic Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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C Pillot-Brochet Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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S Malinge Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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V Ozanne Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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J Vicenzi Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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L Buffat Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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G Perret Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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F Iris Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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M Crepin Unité Inserm U 553, Hôpital St Louis, 75010 Paris, France and Université Paris 13, France
Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Université Paris 13, 93017 Bobigny cedex, France
Valigen, Tour Neptune, 92086 Paris La Défense, France
Ecole Centrale de Paris, Grande voie des vignes 92295 Chatenay Malabry, France and Bio-Modeling Systems, 26 Rue St Lambert, Paris 15, France

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and affect bone, liver and cardiovascular systems ( Sutherland et al. 1988 , Couse & Korach 1999 ). In diseases such as breast cancer, estrogens act as mitogenic factors and are important in tumor initiation and progression in vitro and in vivo

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01631
Volume/Issue:
Volume 34: Issue 1
Free access
Shaheen Khan Departments of Veterinary Physiology and Pharmacology and Biochemistry and Biophysics, Texas A & M University, College Station, Texas 77843-4466, USA The Institute of Biosciences and Technology, Texas A & M University Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA

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Fei Wu Departments of Veterinary Physiology and Pharmacology and Biochemistry and Biophysics, Texas A & M University, College Station, Texas 77843-4466, USA The Institute of Biosciences and Technology, Texas A & M University Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA

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Shengxi Liu Departments of Veterinary Physiology and Pharmacology and Biochemistry and Biophysics, Texas A & M University, College Station, Texas 77843-4466, USA The Institute of Biosciences and Technology, Texas A & M University Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA

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Qian Wu Departments of Veterinary Physiology and Pharmacology and Biochemistry and Biophysics, Texas A & M University, College Station, Texas 77843-4466, USA The Institute of Biosciences and Technology, Texas A & M University Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA

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Stephen Safe Departments of Veterinary Physiology and Pharmacology and Biochemistry and Biophysics, Texas A & M University, College Station, Texas 77843-4466, USA The Institute of Biosciences and Technology, Texas A & M University Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA
Departments of Veterinary Physiology and Pharmacology and Biochemistry and Biophysics, Texas A & M University, College Station, Texas 77843-4466, USA The Institute of Biosciences and Technology, Texas A & M University Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA

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controls if P <0.05. Results Role of Sp proteins of hormonal activation of pSp1 3 Analysis of several gene promoters from E 2 -responsive genes have identified GC-rich motifs that are required for hormone-induced transactivation in breast cancer and other

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-07-0043
Volume/Issue:
Volume 39: Issue 4
Free access
Y-L Zhao Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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W-D Han Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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Q Li Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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Y-M Mu Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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X-C Lu Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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L Yu Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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H-J Song Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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X Li Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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J-M Lu Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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C-Y Pan Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Endocrinology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China
Department of Hematology, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China

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. 1992 , Turner et al . 1994 , Farhat et al . 1996 ). They are also important pathologic factors in the genesis and malignant progression of breast cancer ( Dong et al . 1999 , Khan et al . 2003 ). ERαregulates the transcription of various genes as

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01628
Volume/Issue:
Volume 34: Issue 1
Free access
Changxue Lu Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892-4264, USA

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Sheue-Yann Cheng Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892-4264, USA

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such as obesity, diabetes, and cancer. The first part of this review describes current understanding of PPAR and TR biology. The second part highlights recent advances in the understanding of molecular mechanisms underlying the PPAR–TR crosstalks, with

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0107
Volume/Issue:
Volume 44: Issue 3
Free access
Alberto Cascón Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain

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Bruna Calsina Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

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María Monteagudo Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

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Sara Mellid Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

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Alberto Díaz-Talavera Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain

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Maria Currás-Freixes Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

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Mercedes Robledo Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain

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signs in the patient usually precedes the development of PPGL (‘cafe au lait’ spots in NF1 patients and medullary thyroid cancer (MTC) in MEN2 cases), while in others, there are no previous clinical evidence to suggest a genetic disorder (type 2C VHL

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0167
Volume/Issue:
Volume 70: Issue 3
Free access
Lai Jin Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

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Chuanhua Li Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

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Rong Li Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

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Zongxing Sun Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

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Xianjun Fang Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

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Shengnan Li Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

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regulator, is associated with a growing list of tumors. It has been reported that a few patients with prostate cancer presented CRH secretion ( Carey et al . 1984 , Saeger et al . 1993 , Rickman et al . 2001 ), and urocortin, one of the CRH family

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0270
Volume/Issue:
Volume 52: Issue 3
Free access
Xu-guang Zhu Laboratory of Molecular Biology, Department of Microbiology, National Cancer Institute, National Institutes of Health, Center for Cancer Research, 37 Convent Drive, Room 5128, Bethesda, Marryland 20892-4264, USA

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Dong Wook Kim Laboratory of Molecular Biology, Department of Microbiology, National Cancer Institute, National Institutes of Health, Center for Cancer Research, 37 Convent Drive, Room 5128, Bethesda, Marryland 20892-4264, USA

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Michael L Goodson Laboratory of Molecular Biology, Department of Microbiology, National Cancer Institute, National Institutes of Health, Center for Cancer Research, 37 Convent Drive, Room 5128, Bethesda, Marryland 20892-4264, USA

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Martin L Privalsky Laboratory of Molecular Biology, Department of Microbiology, National Cancer Institute, National Institutes of Health, Center for Cancer Research, 37 Convent Drive, Room 5128, Bethesda, Marryland 20892-4264, USA

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Sheue-Yann Cheng Laboratory of Molecular Biology, Department of Microbiology, National Cancer Institute, National Institutes of Health, Center for Cancer Research, 37 Convent Drive, Room 5128, Bethesda, Marryland 20892-4264, USA

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be perceived as prejudicing the impartiality of the research reported. Funding This research was supported by the Intramural Research Program of Center for Cancer Research, National Cancer Institute, National Institutes of Health. References Araki O

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0163
Volume/Issue:
Volume 46: Issue 3
Free access
S Zhang Department of Veterinary Physiology and Pharmacology,
Department of Veterinary Anatomy and Public Health,
Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA
Institute of Biosciences and Technology, Texas A&M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA

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X Li Department of Veterinary Physiology and Pharmacology,
Department of Veterinary Anatomy and Public Health,
Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA
Institute of Biosciences and Technology, Texas A&M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA

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R Burghardt Department of Veterinary Physiology and Pharmacology,
Department of Veterinary Anatomy and Public Health,
Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA
Institute of Biosciences and Technology, Texas A&M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA

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R Smith III Department of Veterinary Physiology and Pharmacology,
Department of Veterinary Anatomy and Public Health,
Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA
Institute of Biosciences and Technology, Texas A&M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA

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S H Safe Department of Veterinary Physiology and Pharmacology,
Department of Veterinary Anatomy and Public Health,
Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA
Institute of Biosciences and Technology, Texas A&M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA

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including their interaction with IGF-binding proteins, which dramatically modulate the activity and function of these mitogens ( Grimberg & Cohen 2000 ). IGF signaling pathways are important for growth of multiple cancers, and elevated serum IGF-I levels are

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01858
Volume/Issue:
Volume 35: Issue 3
Free access
Svenja Nölting Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and

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Edwin Garcia Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and

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Ghassan Alusi Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and

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Alessio Giubellino Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and

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Karel Pacak Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and

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Márta Korbonits Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and

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Ashley B Grossman Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and
Department of Endocrinology, Barts Cancer Institute, NIH, Oxford Centre for Diabetes, William Harvey Research Institute and

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and AKT signalling in vitro in different cancer cell lines and in vivo in animal models. Consequently, we investigated the effect of lovastatin in both PCC cell lines. We found that 24 h treatment with lovastatin did not affect MPC ( Fig. 4A ) or

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0028
Volume/Issue:
Volume 49: Issue 2
Free access