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Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
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Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
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type. This ability to regulate gene expression in a cell-specific manner is shared by many broadly expressed signal-dependent transcription factors (SDTFs), including other nuclear hormone receptors and members of the diverse families of transcription
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extensive investigation of LIF–STAT and integrin signaling may improve the outcome of embryo implantation and subsequent pregnancy. In this study, we have tried to identify extracted EVs and miRNAs from decidua and decidual stromal cells. miRNA
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Endocrine signaling As early as the 1940s, endocrinology has played a central part in the treatment of prostate cancer (PCa) when Charles Huggins and Clarence Hodges discovered a direct relationship between androgenic hormones and
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-response element (TIRE), has been identified as the likely final target for this insulin-signalling cascade (for review, see O’Brien & Granner 1996 , Sutherland et al. 2003 ). Insulin signalling includes activation of the lipid kinase phosphatidylinositol 3
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2), hormone-sensitive lipase ( Lipe /HSL) and fatty acid synthase ( Fasn /FAS) ( Cornelius et al . 1994 ). Signalling pathways that induce the adipogenic transcriptional machinery remain poorly characterised. It is generally accepted that this
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
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Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
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Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
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Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
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Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
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Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
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Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
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–Fbox (SCF) complex that is responsible for ubiquitin-mediated proteasomal degradation ( Dias et al . 2002 ). The ubiquitin-mediated proteasomal degradation pathway is required for GH receptor endocytosis and regulates downstream signalling molecules
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
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conditions vary, so that the cell can fine-tune its protein content by both increasing the rate of overall translation and/or of only a subset of selective, adaptative mRNA. The signaling mechanisms that control the translational machinery involve changes in
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stress in experimental hyperthyroidism, indicating that reactive oxygen species (ROS) may contribute to the progression to heart failure in this model ( Araujo et al . 2006 ). ROS are integral to the induction and maintenance of many signal transduction
University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
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University of Chinese Academy of Sciences, Beijing, China
Key Laboratory of Drug Target and Drug for Degenerative Disease, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China
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( Peng et al . 2016 ). GLP-1 RAs may also potentially contribute to the development of pancreatitis and increase the risk of pancreatic cancer ( Lamont & Andrikopoulos 2014 ). Thus, it is still urgent to develop new drugs based on new targets or signal(s
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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on bone and decoy receptor for RANKL inhibiting osteoclastogenesis (Mitani et al. 2005) Wnt-1 induced signaling /secreted protein-2 Wisp2 Connective tissue growth factor (Tanaka et al. 2005) Matrix metalloproteinase (MMP)-3