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Dawn X Zhang Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA

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Christopher K Glass Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA

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type. This ability to regulate gene expression in a cell-specific manner is shared by many broadly expressed signal-dependent transcription factors (SDTFs), including other nuclear hormone receptors and members of the diverse families of transcription

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Hsien-Ming Wu Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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Liang-Hsuan Chen Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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Wei-Jung Chiu Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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Chia-Lung Tsai Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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extensive investigation of LIF–STAT and integrin signaling may improve the outcome of embryo implantation and subsequent pregnancy. In this study, we have tried to identify extracted EVs and miRNAs from decidua and decidual stromal cells. miRNA

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Gail P Risbridger Monash Institute of Medical Research, Centre for Urological Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia

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Stuart J Ellem Monash Institute of Medical Research, Centre for Urological Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia

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Stephen J McPherson Monash Institute of Medical Research, Centre for Urological Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia

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Endocrine signaling As early as the 1940s, endocrinology has played a central part in the treatment of prostate cancer (PCa) when Charles Huggins and Clarence Hodges discovered a direct relationship between androgenic hormones and

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David Finlay Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK

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Antonio J Ruiz-Alcaraz Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK

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Christopher Lipina Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK

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Stephane Perrier Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK

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Calum Sutherland Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK

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-response element (TIRE), has been identified as the likely final target for this insulin-signalling cascade (for review, see O’Brien & Granner 1996 , Sutherland et al. 2003 ). Insulin signalling includes activation of the lipid kinase phosphatidylinositol 3

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Amélie Gormand
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Christine Berggreen
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Lahouari Amar
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Emma Henriksson
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Ingrid Lund Department of Experimental Medical Science, Department of Biomedicine, Lund University, BMC C11, 221 84 Lund, Sweden

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Sebastian Albinsson
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Olga Göransson
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2), hormone-sensitive lipase ( Lipe /HSL) and fatty acid synthase ( Fasn /FAS) ( Cornelius et al . 1994 ). Signalling pathways that induce the adipogenic transcriptional machinery remain poorly characterised. It is generally accepted that this

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D Hanson Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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P G Murray Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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T Coulson Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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A Sud Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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A Omokanye Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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E Stratta Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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F Sakhinia Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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C Bonshek Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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L C Wilson Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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E Wakeling Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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S A Temtamy Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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M Aglan Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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E M Rosser Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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S Mansour Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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A Carcavilla Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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S Nampoothiri Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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W I Khan Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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I Banerjee Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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K E Chandler Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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G C M Black Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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P E Clayton Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
Paediatric Endocrinology, Genetic Medicine Research Group, Central Manchester University Hospitals Foundation Trust, Clinical Genetics, North West Thames Regional Genetic Service, Division of Human Genetics and Human Genome Research, South-West Thames Regional Genetics Service, Pediatrics Department, Department of Pediatric Genetics, Department of Endocrinology, School of Biomedicine, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK

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–Fbox (SCF) complex that is responsible for ubiquitin-mediated proteasomal degradation ( Dias et al . 2002 ). The ubiquitin-mediated proteasomal degradation pathway is required for GH receptor endocytosis and regulates downstream signalling molecules

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Kelly León UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Thomas Boulo UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Astrid Musnier UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Julia Morales UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Christophe Gauthier UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Laurence Dupuy UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Steffen Heyne UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Rolf Backofen UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Anne Poupon UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Patrick Cormier UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Eric Reiter UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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Pascale Crepieux UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France
UMR85, Group «Biology and Bioinformatics of Signaling Systems (BIOS)», Université François Rabelais, IFCE, Université Pierre et Marie Curie, Université Européenne de Bretagne, Bioinformatics Group, Unité Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France

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conditions vary, so that the cell can fine-tune its protein content by both increasing the rate of overall translation and/or of only a subset of selective, adaptative mRNA. The signaling mechanisms that control the translational machinery involve changes in

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A S R Araujo
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P Schenkel
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A T Enzveiler
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T R G Fernandes
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W A Partata
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S Llesuy Departamento de Fisiologia, Cátedra de Química General y Inorgánica, Medical Sciences Division, Faculty of Medicine, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, RS, Brazil

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M F M Ribeiro
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N Khaper Departamento de Fisiologia, Cátedra de Química General y Inorgánica, Medical Sciences Division, Faculty of Medicine, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, RS, Brazil

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P K Singal Departamento de Fisiologia, Cátedra de Química General y Inorgánica, Medical Sciences Division, Faculty of Medicine, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, RS, Brazil

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A Belló-Klein
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stress in experimental hyperthyroidism, indicating that reactive oxygen species (ROS) may contribute to the progression to heart failure in this model ( Araujo et al . 2006 ). ROS are integral to the induction and maintenance of many signal transduction

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Ting-Ting Zhou Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Fei Ma School of Pharmacy, East China University of Science and Technology, Shanghai, China

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Xiao-Fan Shi Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xin Xu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Te Du Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xiao-Dan Guo Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Gai-Hong Wang Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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Liang Yu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Vatcharin Rukachaisirikul Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand

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Li-Hong Hu Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Jing Chen Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China

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Xu Shen Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
University of Chinese Academy of Sciences, Beijing, China
Key Laboratory of Drug Target and Drug for Degenerative Disease, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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( Peng et al . 2016 ). GLP-1 RAs may also potentially contribute to the development of pancreatitis and increase the risk of pancreatic cancer ( Lamont & Andrikopoulos 2014 ). Thus, it is still urgent to develop new drugs based on new targets or signal(s

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Debolina Chakraborty Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Ashish Sarkar Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Sonia Mann Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India

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Monu Monu Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Prachi Agnihotri Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Mohd Saquib Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Swati Malik Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Rajkamal Kumavat Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Anushka Mathur Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India

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Sagarika Biswas Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Delhi, India

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on bone and decoy receptor for RANKL inhibiting osteoclastogenesis (Mitani et al. 2005) Wnt-1 induced signaling /secreted protein-2 Wisp2 Connective tissue growth factor (Tanaka et al. 2005) Matrix metalloproteinase (MMP)-3

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