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of circHIPK3 ( Liu et al. 2017 ). CircHIPK3 was found to sponge and suppress miR-30a-3p, thereby activating WNT2, FZD4, and VEGFC and exerting its protective effect against endothelial dysfunction under high-glucose conditions ( Shan et al. 2017
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– 2879 . ( https://doi.org/10.1074/jbc.M608083200 ) Dakeng S Duangmano S Jiratchariyakul W U-Pratya Y Bögler O Patmasiriwat P 2012 Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins
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–phosphatidylinositol 3-kinase (PI3K) pathway, β-catenin/WNT pathway ( Ghosh-Choudhury et al . 2002 , He et al . 2004 , Nohe et al . 2004 ) and the stress activated protein kinase–c-JUN N-terminal kinase (SAPK/JNK) pathway ( Goto et al . 2009 ). This crosstalk can
Facultad de Ciencias, INRA, Oceanología, Iguá 4225, Montevideo 11400, Uruguay
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, Fst has been proposed as an early ovarian differentiation gene ( Yao et al . 2004 , Yao 2005 ), acting downstream of Wnt4 Yao et al . (2004 , 2006 ) to antagonize the testis-specific formation of the coelomic vessels. The fact that fst
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important pathways included the mitogen-activated protein kinase (MAPK) signaling pathway, focal adhesion, Wnt signaling pathway, extracellular matrix (ECM)–receptor interaction and cell communication, and cell apoptosis. The full table of RA target genes
Department of Veterinary Physiology and Pharmacology, Institute of Biosciences and Technology, Veterinary Integrative Biosciences, Biochemistry and Biophysics, Texas A&M University, 4466 TAMU, Veterinary Research Building 410, College Station, Texas 77843-4466, USA
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Department of Veterinary Physiology and Pharmacology, Institute of Biosciences and Technology, Veterinary Integrative Biosciences, Biochemistry and Biophysics, Texas A&M University, 4466 TAMU, Veterinary Research Building 410, College Station, Texas 77843-4466, USA
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. Kouzmenko AP Takeyama K Ito S Furutani T Sawatsubashi S Maki A Suzuki E Kawasaki Y Akiyama T Tabata T 2004 Wnt/β-catenin and estrogen signaling converge in vivo . Journal of Biological Chemistry 279 40255 – 40258 . doi:10
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Role Mechanism of interaction Functional studies References SIX3 Homeobox transcription factor important for eye and pituitary development Regulates through the WNT/β-catenin signaling pathway to allow normal forebrain development Six3+/− Hesx1Cre
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pathways and may impact Wnt signaling, a pathway crucial for adrenal development and tissue maintenance ( Sarin et al . 2005 , Choi et al . 2008 , Kim et al . 2008 , Venteicher et al . 2008 ). AHC with cytomegaly has been well described in human
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proliferation through the inhibition of the Wnt-signaling pathway ( Zhang et al . 2008 ) and act as a negative regulator of chondrogenesis ( Tominaga et al . 2009 ). Osx expression has also been suggested to play a role in tumor growth and metastasis, and
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demonstrated that the activating mutation Arg201Cys in GNAS cooperates with inactivation of adenomatous polyposis coli to promote intestinal tumorigenesis in mice through activation of Wnt and ERK1/2 MAPK pathways ( Wilson et al . 2010 ). Figure 2 Genomic
