Insulin resistance and type 2 diabetes mellitus


Insulin resistance and type 2 diabetes special collection banner


The Editorial Board of Journal of Endocrinology and Journal of Molecular Endocrinology is developing a collection of articles focused on the molecular mechanisms behind the development of insulin resistance and type 2 diabetes mellitus.

Led by Guest Editors Professor Matthias Blüher and Professor Stefan Bornstein alongside co-Editor-in-Chief Professor Martin Haluzík, this collection will provide researchers with a comprehensive update on the latest developments in the field of insulin resistance from across the globe, through a series of invited reviews and recent research.

“Insulin resistance is a hallmark of several highly prevalent diseases including type 2 diabetes, obesity, fatty liver disease and others. Insulin resistance may derive from the interaction of environmental, behavior and genetic factors. Very recently the importance of adipose tissue/gut–brain cross-talk including microbiota has become a focus in the study of impaired insulin action. A better understanding of the causative mechanisms of insulin resistance may define novel treatment targets for cardio-metabolic diseases.“
Professor Matthias Blüher, Guest Editor

“I am delighted to invite the authors to submit the papers to this special collection on the very important topic of insulin resistance. Numerous chronic diseases such type 2 diabetes mellitus, obesity, non-alcoholic fatty liver disease and many others are closely interconnected with or directly induced by the presence of insulin resistance. Better knowledge of its etiopathogenesis or mechanism of its prevention and treatment may thus pave the way towards novel approaches to deal with numerous widespread chronic lifestyle diseases, in particular type 2 diabetes mellitus and obesity.“
Professor Martin Haluzík, Editor-in-Chief


The Editors will be pleased to receive submissions of relevant research or reviews to be published as part of this collection. The following topics are of particular interest:

  • Novel mechanisms of type 2 diabetes etiopathogenesis such as cellular senescence
  • New in vitro and in vivo models of insulin resistance and type 2 diabetes
  • Interactions between insulin resistance, type 2 diabetes and their comorbidities (obesity, arterial hypertension, dyslipidemia, cancer)
  • How infection can drive insulin resistance.

If you are interested in contributing a research or review article to this collection, please submit your article proposal to


Collection Editors

photo of Matthias Blüher

Professor Matthias Blüher, Guest Editor
Professor of Molecular Endocrinology
Department of Medicine
University of Leipzig
Leipzig, Germany

photo of Stefan Bornstein

Professor Stefan Bornstein, Guest Editor
Chair of Internal Medicine
University Clinic Carl Gustav Carus
Dresden, Germany

photo of Martin Haluzík

Professor Martin Haluzík, Editor-in-Chief
Professor of Internal Medicine
Charles University
Prague, Czech Republic


Published articles:


Journal of Endocrinology logo

Neuronal insulin signaling and resistance: a balancing act of kinases and phosphatases
Medha Sharma, Yamini Yadav, and Chinmoy Sankar Dey

Do adipocytes serve as a reservoir for severe acute respiratory syndrome coronavirus-2?
Charlotte Steenblock, Nicole Bechmann, Felix Beuschlein, Christian Wolfrum, and Stefan R Bornstein

In vivo techniques for assessment of insulin sensitivity and glucose metabolism
Margaret K Hahn, Adria Giacca, and Sandra Pereira

Sex-based differences in insulin resistance
Manuel Gado, Eva Tsaousidou, Stefan R Bornstein and Nikolaos Perakakis

Gestational exposure to cannabidiol leads to glucose intolerance in 3-month-old male offspring
Sebastian R Vanin, Kendrick Lee, Mina Nashed, Brennan Tse, Mohammed Sarikahya, Sukham Brar, Gregg Tomy, Amica-Mariae Lucas, Thane Tomy, Steven R Laviolette, Edith J Arany and Daniel B Hardy

In vivo models of gestational and type 2 diabetes mellitus characterized by endocrine pancreas cell impairments
Sandra K Szlapinski and David J Hill

Role of CD20+ T cells in cancer, autoimmunity and obesity
Aryane Cruz Oliveira Pinho, Paula Laranjeira, and Eugenia Carvalho


Journal of Molecular Endocrinology logo

Maternal obesity attenuates PPARγ nuclear migration impairing offspring adipogenesis
Érica de Sousa and Alice Cristina Rodrigues

G6PC1 and G6PC2 influence glucose-6-phosphate flux but not 11β-hydroxysteroid dehydrogenase type 1 activity
Emily M Hawes, Kayla A Boortz, James K Oeser, Margaret L O'Rourke, and Richard M O'Brien