Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2/FOXE1

in Journal of Molecular Endocrinology
Authors:
Michela ZamboniM Zamboni, Departement of Biological Sciences, Institute of Biochemistry and Cell Biology National Research Council Monterotondo Branch, Monterotondo Scalo, Italy

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Georgios StrimpakosG Strimpakos, Departement of biological sciences, Institute of Biochemistry and Cell Biology National Research Council Monterotondo Branch, Monterotondo Scalo, Italy

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Eleonora PoggiogalleE Poggiogalle, Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy

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Lorenzo Maria DoniniL Donini, Experimental Medicine- Physiopathology, Food Science and Endocrinology Section- Food Science and Human Nutrition Research Unit, University of Rome La Sapienza, Rome, Italy

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Donato CivitarealeD Civitareale, Department of Biomedical Sciences, Institute of Biochemistry and Cell Biology National Research Council Monterotondo Branch, Monterotondo Scalo, Italy

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Correspondence: Donato Civitareale, Email: donato.civitareale@ibbc.cnr.it
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Obesity affects thyroid gland function. Hypothyroidism, thyroid nodules, goiter, and thyroid cancer are more frequent in patients with higher body mass index values. Although these data are supported by many clinical and epidemiological studies, very scarce is our knowledge at the molecular level. In this study, we present the first experimental evidence that adipocyte signaling down-regulates the expression of thyroid-specific transcription factor 2 (TTF-2/FOXE1). It plays a crucial role in thyroid development and thyroid homeostasis and it is strictly connected to thyroid cancer as well. We provide in vivo and in vitro evidence that inhibition of TTF-2/FOXE1 gene expression is mediated by adipocyte signaling.

 

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