Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2/FOXE1

in Journal of Molecular Endocrinology
Authors:
Michela ZamboniInstitute of Biochemistry and Cell Biology, National Council of Research, Monterotondo, Rome, Italy

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Georgios StrimpakosInstitute of Biochemistry and Cell Biology, National Council of Research, Monterotondo, Rome, Italy

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Eleonora PoggiogalleDepartment of Experimental Medicine – Medical Pathophysiology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy

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Lorenzo M DoniniDepartment of Experimental Medicine – Medical Pathophysiology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy

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Donato CivitarealeInstitute of Biochemistry and Cell Biology, National Council of Research, Monterotondo, Rome, Italy

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https://orcid.org/0000-0001-5719-9098

Correspondence should be addressed to D Civitareale: donato.civitareale@ibbc.cnr.it
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Obesity affects thyroid gland function. Hypothyroidism, thyroid nodules, goiter, and thyroid cancer are more frequent in patients with higher BMI values. Although these data are supported by many clinical and epidemiological studies, our knowledge is very scarce at the molecular level. In this study, we present the first experimental evidence that adipocyte signaling downregulates the expression of thyroid-specific transcription factor 2 (TTF-2/FoxE1). It plays a crucial role in thyroid development and thyroid homeostasis and it is strictly connected to thyroid cancer as well. We provide in vivo and in vitro evidence that inhibition of TTF-2/FoxE1 gene expression is mediated by adipocyte signaling.

 

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