The growth hormone-dependent decrease in hepatic fatty acid synthase mRNA is the result of a decrease in gene transcription

in Journal of Molecular Endocrinology
Authors:
S S Donkin
Search for other papers by S S Donkin in
Current site
Google Scholar
PubMed
Close
,
A D McNall
Search for other papers by A D McNall in
Current site
Google Scholar
PubMed
Close
,
B S Swencki
Search for other papers by B S Swencki in
Current site
Google Scholar
PubMed
Close
,
J L Peters
Search for other papers by J L Peters in
Current site
Google Scholar
PubMed
Close
, and
T D Etherton
Search for other papers by T D Etherton in
Current site
Google Scholar
PubMed
Close
View More View Less
Restricted access

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $0.01
USD  $0.01

USD  $1.00
USD  $1.00

USD  $1.00
USD  $1.00

USD  $1.00
USD  $1.00

ABSTRACT

The present study was conducted to determine the chronic effects of porcine growth hormone administration on fatty acid synthase (FAS) mRNA abundance and gene transcription in growing rats. Growth hormone treatment increased growth rate approximately 27% (P<0·01). Porcine growth hormone decreased FAS mRNA levels by 55%. The reduction in FAS mRNA was due to a marked decrease in transcription of the FAS gene (decreased by 80%). In contrast, porcine growth hormone did not affect mRNA abundance or transcription rate of another insulin-regulated gene, phosphoenolpyruvate carboxykinase. In summary, our results have established that chronic treatment with growth hormone decreases FAS mRNA by decreasing the transcription rate of the gene. Furthermore, they suggest that the effects of growth hormone are specific and are not mediated by general changes in insulin-responsive gene expression in liver.

 

  • Collapse
  • Expand